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- W2943944967 abstract "The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of alpha-synuclein from both the intracellular and extracellular environment. Proteasomes and lysosomes are likely to play complementary roles in the removal of intracellular alpha-synuclein species, in a manner that depends on alpha-synuclein post-translational modifications. Extracellular alpha-synuclein is cleared by extracellular proteolytic enzymes, or taken up by neighboring cells, especially microglia and astrocytes, and degraded within lysosomes. Exosomes, on the other hand, represent a vehicle for egress of excess burden of the intracellular protein, potentially contributing to the transfer of alpha-synuclein between cells. Dysfunction in any one of these clearance mechanisms, or a combination thereof, may be involved in the initiation or progression of Parkinson's disease, whereas targeting these pathways may offer an opportunity for therapeutic intervention. This article is part of the Special Issue Synuclein." @default.
- W2943944967 created "2019-05-16" @default.
- W2943944967 creator A5019613030 @default.
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- W2943944967 creator A5083016310 @default.
- W2943944967 creator A5083251583 @default.
- W2943944967 creator A5089947731 @default.
- W2943944967 date "2019-05-08" @default.
- W2943944967 modified "2023-10-18" @default.
- W2943944967 title "How is alpha‐synuclein cleared from the cell?" @default.
- W2943944967 cites W1494109356 @default.
- W2943944967 cites W1558608994 @default.
- W2943944967 cites W1585155225 @default.
- W2943944967 cites W1630502818 @default.
- W2943944967 cites W1907174433 @default.
- W2943944967 cites W1965888147 @default.
- W2943944967 cites W1971302334 @default.
- W2943944967 cites W1971483465 @default.
- W2943944967 cites W1977015834 @default.
- W2943944967 cites W1977266560 @default.
- W2943944967 cites W1977977555 @default.
- W2943944967 cites W1979591162 @default.
- W2943944967 cites W1984136850 @default.
- W2943944967 cites W1989732798 @default.
- W2943944967 cites W1990167863 @default.
- W2943944967 cites W1991322550 @default.
- W2943944967 cites W1993467627 @default.
- W2943944967 cites W1996298454 @default.
- W2943944967 cites W1998079639 @default.
- W2943944967 cites W2009659096 @default.
- W2943944967 cites W2010102311 @default.
- W2943944967 cites W2011779831 @default.
- W2943944967 cites W2014299620 @default.
- W2943944967 cites W2014413787 @default.
- W2943944967 cites W2015278187 @default.
- W2943944967 cites W2015957622 @default.
- W2943944967 cites W2016384173 @default.
- W2943944967 cites W2017642230 @default.
- W2943944967 cites W2022285303 @default.
- W2943944967 cites W2022649483 @default.
- W2943944967 cites W2026175550 @default.
- W2943944967 cites W2026969412 @default.
- W2943944967 cites W2027096397 @default.
- W2943944967 cites W2027649342 @default.
- W2943944967 cites W2028380145 @default.
- W2943944967 cites W2029646606 @default.
- W2943944967 cites W2030025610 @default.
- W2943944967 cites W2031754652 @default.
- W2943944967 cites W2038272035 @default.
- W2943944967 cites W2039841560 @default.
- W2943944967 cites W2045244036 @default.
- W2943944967 cites W2048383114 @default.
- W2943944967 cites W2048721771 @default.
- W2943944967 cites W2049111527 @default.
- W2943944967 cites W2052302154 @default.
- W2943944967 cites W2057358353 @default.
- W2943944967 cites W2060526494 @default.
- W2943944967 cites W2060575579 @default.
- W2943944967 cites W2062224058 @default.
- W2943944967 cites W2065236536 @default.
- W2943944967 cites W2068001820 @default.
- W2943944967 cites W2068288454 @default.
- W2943944967 cites W2069537999 @default.
- W2943944967 cites W2070575993 @default.
- W2943944967 cites W2071622491 @default.
- W2943944967 cites W2073076870 @default.
- W2943944967 cites W2073852487 @default.
- W2943944967 cites W2074649216 @default.
- W2943944967 cites W2075906033 @default.
- W2943944967 cites W2076592306 @default.
- W2943944967 cites W2077757969 @default.
- W2943944967 cites W2083835014 @default.
- W2943944967 cites W2084864591 @default.
- W2943944967 cites W2090926836 @default.
- W2943944967 cites W2095499213 @default.
- W2943944967 cites W2096245387 @default.
- W2943944967 cites W2106318486 @default.
- W2943944967 cites W2107451956 @default.
- W2943944967 cites W2108865709 @default.
- W2943944967 cites W2117626437 @default.
- W2943944967 cites W2117822586 @default.
- W2943944967 cites W2118518385 @default.
- W2943944967 cites W2119048511 @default.
- W2943944967 cites W2121981334 @default.
- W2943944967 cites W2123869107 @default.
- W2943944967 cites W2126478464 @default.
- W2943944967 cites W2127342428 @default.
- W2943944967 cites W2128631317 @default.
- W2943944967 cites W2130371399 @default.
- W2943944967 cites W2131730392 @default.
- W2943944967 cites W2139180375 @default.
- W2943944967 cites W2141976392 @default.
- W2943944967 cites W2143515674 @default.
- W2943944967 cites W2144370836 @default.
- W2943944967 cites W2146706912 @default.
- W2943944967 cites W2147461093 @default.
- W2943944967 cites W2151993274 @default.