Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943954071> ?p ?o ?g. }
- W2943954071 abstract "Abstract Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. However, no studies have investigated pan-cancer pleiotropy within single, well-defined populations unselected for phenotype. We undertook novel genome-wide association studies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in two large, population-based cohorts: the UK Biobank (413,870 European ancestry individuals; 48,961 cancer cases) and the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging cohorts (66,526 European ancestry individuals; 16,001 cancer cases). The GWAS detected 21 novel genome-wide significant risk variants. In addition, numerous cancer sites exhibited clear heritability. Investigations of pleiotropy identified 12 cancer pairs exhibiting either positive or negative genetic correlations and 43 pleiotropic loci. We identified 158 pleiotropic variants, many of which were enriched for regulatory elements and influenced cross-tissue gene expression. Our findings demonstrate widespread pleiotropy and offer further insight into the complex genetic architecture of cross-cancer susceptibility." @default.
- W2943954071 created "2019-05-16" @default.
- W2943954071 creator A5003524681 @default.
- W2943954071 creator A5011389324 @default.
- W2943954071 creator A5016959999 @default.
- W2943954071 creator A5017728402 @default.
- W2943954071 creator A5023847764 @default.
- W2943954071 creator A5029294320 @default.
- W2943954071 creator A5031698839 @default.
- W2943954071 creator A5035070420 @default.
- W2943954071 creator A5037291379 @default.
- W2943954071 creator A5044332098 @default.
- W2943954071 creator A5046031453 @default.
- W2943954071 creator A5047242356 @default.
- W2943954071 creator A5051264184 @default.
- W2943954071 creator A5055941002 @default.
- W2943954071 creator A5057537193 @default.
- W2943954071 creator A5059983157 @default.
- W2943954071 creator A5065526095 @default.
- W2943954071 creator A5084656451 @default.
- W2943954071 creator A5087681848 @default.
- W2943954071 date "2019-05-11" @default.
- W2943954071 modified "2023-10-16" @default.
- W2943954071 title "Pan-Cancer Study Detects Novel Genetic Risk Variants and Shared Genetic Basis in Two Large Cohorts" @default.
- W2943954071 cites W1840403001 @default.
- W2943954071 cites W1844405070 @default.
- W2943954071 cites W1977546001 @default.
- W2943954071 cites W1992436001 @default.
- W2943954071 cites W1994769604 @default.
- W2943954071 cites W2004429375 @default.
- W2943954071 cites W2022815972 @default.
- W2943954071 cites W2033151532 @default.
- W2943954071 cites W2039310245 @default.
- W2943954071 cites W2041144936 @default.
- W2943954071 cites W2048462000 @default.
- W2943954071 cites W2055869166 @default.
- W2943954071 cites W2061539393 @default.
- W2943954071 cites W2070440163 @default.
- W2943954071 cites W2071818455 @default.
- W2943954071 cites W2076154138 @default.
- W2943954071 cites W2076411581 @default.
- W2943954071 cites W2081067541 @default.
- W2943954071 cites W2081596026 @default.
- W2943954071 cites W2088335869 @default.
- W2943954071 cites W2099085143 @default.
- W2943954071 cites W2100630465 @default.
- W2943954071 cites W2102213696 @default.
- W2943954071 cites W2106187803 @default.
- W2943954071 cites W2106675244 @default.
- W2943954071 cites W2111307685 @default.
- W2943954071 cites W2112227066 @default.
- W2943954071 cites W2116005837 @default.
- W2943954071 cites W2118496272 @default.
- W2943954071 cites W2123164802 @default.
- W2943954071 cites W2129579028 @default.
- W2943954071 cites W2130410032 @default.
- W2943954071 cites W2131297253 @default.
- W2943954071 cites W2135456872 @default.
- W2943954071 cites W2135665336 @default.
- W2943954071 cites W2144287526 @default.
- W2943954071 cites W2152885121 @default.
- W2943954071 cites W2153860431 @default.
- W2943954071 cites W2158740417 @default.
- W2943954071 cites W2161633633 @default.
- W2943954071 cites W2164752398 @default.
- W2943954071 cites W2166320441 @default.
- W2943954071 cites W2166334861 @default.
- W2943954071 cites W2169248969 @default.
- W2943954071 cites W2195783463 @default.
- W2943954071 cites W2198606573 @default.
- W2943954071 cites W2207695604 @default.
- W2943954071 cites W2225530246 @default.
- W2943954071 cites W2284253967 @default.
- W2943954071 cites W2336130565 @default.
- W2943954071 cites W2398690791 @default.
- W2943954071 cites W2408363066 @default.
- W2943954071 cites W2515138490 @default.
- W2943954071 cites W2517068497 @default.
- W2943954071 cites W2560048039 @default.
- W2943954071 cites W2570401594 @default.
- W2943954071 cites W2580024686 @default.
- W2943954071 cites W2580791746 @default.
- W2943954071 cites W2588680423 @default.
- W2943954071 cites W2601822003 @default.
- W2943954071 cites W2609876203 @default.
- W2943954071 cites W2612427157 @default.
- W2943954071 cites W2644301481 @default.
- W2943954071 cites W2761275051 @default.
- W2943954071 cites W2765253743 @default.
- W2943954071 cites W2767142305 @default.
- W2943954071 cites W2770092353 @default.
- W2943954071 cites W2777667999 @default.
- W2943954071 cites W2806504012 @default.
- W2943954071 cites W2856147698 @default.
- W2943954071 cites W2887705062 @default.
- W2943954071 cites W2888796627 @default.
- W2943954071 cites W2889646458 @default.
- W2943954071 cites W2891436740 @default.
- W2943954071 cites W2892220808 @default.
- W2943954071 cites W2895486342 @default.