FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943954870> ?p ?o ?g. }

• W2943954870 endingPage "361" @default.
• W2943954870 startingPage "353" @default.
• W2943954870 abstract "Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC." @default.
• W2943954870 created "2019-05-16" @default.
• W2943954870 creator A5006104652 @default.
• W2943954870 creator A5009108850 @default.
• W2943954870 creator A5011345472 @default.
• W2943954870 creator A5015199856 @default.
• W2943954870 creator A5028051504 @default.
• W2943954870 creator A5053644169 @default.
• W2943954870 creator A5059710213 @default.
• W2943954870 creator A5068122421 @default.
• W2943954870 creator A5081832114 @default.
• W2943954870 creator A5081960020 @default.
• W2943954870 creator A5084305901 @default.
• W2943954870 creator A5085866021 @default.
• W2943954870 creator A5087716350 @default.
• W2943954870 date "2019-07-01" @default.
• W2943954870 modified "2023-10-03" @default.
• W2943954870 title "Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies" @default.
• W2943954870 cites W1226027321 @default.
• W2943954870 cites W1544673104 @default.
• W2943954870 cites W1563878414 @default.
• W2943954870 cites W1968812902 @default.
• W2943954870 cites W1972374829 @default.
• W2943954870 cites W1977343641 @default.
• W2943954870 cites W1988892193 @default.
• W2943954870 cites W1990963105 @default.
• W2943954870 cites W1996066332 @default.
• W2943954870 cites W2016537201 @default.
• W2943954870 cites W2016906423 @default.
• W2943954870 cites W2022105278 @default.
• W2943954870 cites W2024301216 @default.
• W2943954870 cites W2036333816 @default.
• W2943954870 cites W2042638841 @default.
• W2943954870 cites W2043041648 @default.
• W2943954870 cites W2055094817 @default.
• W2943954870 cites W2061066196 @default.
• W2943954870 cites W2065633977 @default.
• W2943954870 cites W2066635729 @default.
• W2943954870 cites W2068988434 @default.
• W2943954870 cites W2071629003 @default.
• W2943954870 cites W2072754176 @default.
• W2943954870 cites W2083904574 @default.
• W2943954870 cites W2092360198 @default.
• W2943954870 cites W2100018617 @default.
• W2943954870 cites W2103848508 @default.
• W2943954870 cites W2104354166 @default.
• W2943954870 cites W2135706299 @default.
• W2943954870 cites W2144869210 @default.
• W2943954870 cites W2153909256 @default.
• W2943954870 cites W2155169848 @default.
• W2943954870 cites W2159661569 @default.
• W2943954870 cites W2160870978 @default.
• W2943954870 cites W2161817637 @default.
• W2943954870 cites W2162049864 @default.
• W2943954870 cites W2165389059 @default.
• W2943954870 cites W2177410571 @default.
• W2943954870 cites W2279030154 @default.
• W2943954870 cites W2292491339 @default.
• W2943954870 cites W2312473524 @default.
• W2943954870 cites W2316540207 @default.
• W2943954870 cites W2411226368 @default.
• W2943954870 cites W2511201574 @default.
• W2943954870 cites W2600405754 @default.
• W2943954870 cites W2610414002 @default.
• W2943954870 cites W2769018203 @default.
• W2943954870 cites W2788018666 @default.
• W2943954870 cites W2790634443 @default.
• W2943954870 cites W2804676384 @default.
• W2943954870 cites W2806770648 @default.
• W2943954870 cites W2889646458 @default.
• W2943954870 cites W2909080269 @default.
• W2943954870 cites W4230920228 @default.
• W2943954870 doi "https://doi.org/10.1016/j.envint.2019.04.048" @default.
• W2943954870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31078004" @default.
• W2943954870 hasPublicationYear "2019" @default.
• W2943954870 type Work @default.
• W2943954870 sameAs 2943954870 @default.
• W2943954870 citedByCount "82" @default.
• W2943954870 countsByYear W29439548702019 @default.
• W2943954870 countsByYear W29439548702020 @default.
• W2943954870 countsByYear W29439548702021 @default.
• W2943954870 countsByYear W29439548702022 @default.
• W2943954870 countsByYear W29439548702023 @default.
• W2943954870 crossrefType "journal-article" @default.
• W2943954870 hasAuthorship W2943954870A5006104652 @default.
• W2943954870 hasAuthorship W2943954870A5009108850 @default.
• W2943954870 hasAuthorship W2943954870A5011345472 @default.
• W2943954870 hasAuthorship W2943954870A5015199856 @default.
• W2943954870 hasAuthorship W2943954870A5028051504 @default.
• W2943954870 hasAuthorship W2943954870A5053644169 @default.
• W2943954870 hasAuthorship W2943954870A5059710213 @default.
• W2943954870 hasAuthorship W2943954870A5068122421 @default.
• W2943954870 hasAuthorship W2943954870A5081832114 @default.
• W2943954870 hasAuthorship W2943954870A5081960020 @default.
• W2943954870 hasAuthorship W2943954870A5084305901 @default.
• W2943954870 hasAuthorship W2943954870A5085866021 @default.
• W2943954870 hasAuthorship W2943954870A5087716350 @default.
• W2943954870 hasBestOaLocation W29439548701 @default.

• next