FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944014003> ?p ?o ?g. }

• W2944014003 endingPage "228" @default.
• W2944014003 startingPage "219" @default.
• W2944014003 abstract "The combination of chemotherapy with photodynamic therapy (PDT) holds promising applications in cancer therapy. However, co-encapsulation of chemotherapeutic agents and photosensitizers (PS) into the conventional nanocarriers suffers from inefficient co-loading and aggregation-caused quenching (ACQ) effect of PS trapped in dense carrier materials. Herein, we report a light-activatable photodynamic PEG-coated prodrug nanoplatform for core-shell synergistic chemo-photodynamic therapy. A novel photodynamic polymer is rationally designed and synthesized by conjugating pyropheophorbide a (PPa) to polyethylene glycol 2000 (PEG2k). PPa is used as the hydrophobic and photodynamic moiety of the amphipathic PPa-PEG2k polymer. Then, a core-shell nanoassembly is prepared, with an inner core of a reactive oxygen species (ROS)-responsive oleate prodrug of paclitaxel (PTX) and an outer layer of PPa-PEG2k. PPa-PEG2k serves for both PEGylation and PDT. Instead of being trapped in the inner core, PPa in the outer PPa-PEG2k layer significantly alleviates the ACQ effect. Under laser irradiation, ROS generated by PPa-PEG2k not only is used for PDT but also synergistically promotes PTX release in combination with the endogenous ROS overproduced in tumor cells. The photodynamic PEG-coated nanoassemblies demonstrated synergistic antitumor activity in vivo. Such a unique nanoplatform, with an inner chemotherapeutic core and an outer photodynamic PEG shell, provides a new strategy for synergistic chemo-photodynamic therapy. STATEMENT OF SIGNIFICATION: The combination of chemotherapy with photodynamic therapy (PDT) holds promising prospects in cancer therapy. However, it remains a tremendous challenge to effectively co-deliver chemotherapeutic drugs and photosensitizers into tumors. Herein, we construct a photodynamic PEGylation-coated prodrug-nanoplatform for high-efficiency synergistic cancer therapy, which is composed of a light-activatable PPa-PEG2k shell and a ROS-responsive paclitaxel (PTX) prodrug core. The PPa-PEG2k-generated ROS not only was used for synergistic PTX release but also synergistically facilitated tumor cell apoptosis in combination with PTX-initiated chemo-cytotoxicity. The light-activatable nanoassemblies exhibited multiple drug delivery advantages including high co-loading efficiency, self-enhanced PTX release, extended circulation time, favorable biodistribution, and potent synergistic anticancer activity. Our findings provide a new strategy for the rational design of advanced nano-DDS for high-efficiency combinational chemo-photodynamic therapy." @default.
• W2944014003 created "2019-05-16" @default.
• W2944014003 creator A5002187196 @default.
• W2944014003 creator A5005186305 @default.
• W2944014003 creator A5013038112 @default.
• W2944014003 creator A5041105225 @default.
• W2944014003 creator A5047932271 @default.
• W2944014003 creator A5062871251 @default.
• W2944014003 creator A5064323494 @default.
• W2944014003 creator A5078835329 @default.
• W2944014003 creator A5082012643 @default.
• W2944014003 creator A5086013055 @default.
• W2944014003 date "2019-07-01" @default.
• W2944014003 modified "2023-10-07" @default.
• W2944014003 title "Photodynamic PEG-coated ROS-sensitive prodrug nanoassemblies for core-shell synergistic chemo-photodynamic therapy" @default.
• W2944014003 cites W1535670011 @default.
• W2944014003 cites W1596848781 @default.
• W2944014003 cites W1748067466 @default.
• W2944014003 cites W1976589118 @default.
• W2944014003 cites W2015006203 @default.
• W2944014003 cites W2083887808 @default.
• W2944014003 cites W2167452847 @default.
• W2944014003 cites W2206020846 @default.
• W2944014003 cites W2257916459 @default.
• W2944014003 cites W2300197534 @default.
• W2944014003 cites W2317661976 @default.
• W2944014003 cites W2320574135 @default.
• W2944014003 cites W2327890634 @default.
• W2944014003 cites W2367790775 @default.
• W2944014003 cites W2468136693 @default.
• W2944014003 cites W2474783963 @default.
• W2944014003 cites W2503470809 @default.
• W2944014003 cites W2515854919 @default.
• W2944014003 cites W2528255417 @default.
• W2944014003 cites W2576090363 @default.
• W2944014003 cites W2611363212 @default.
• W2944014003 cites W2747169234 @default.
• W2944014003 cites W2759827498 @default.
• W2944014003 cites W2774500577 @default.
• W2944014003 cites W2783808730 @default.
• W2944014003 cites W2792905714 @default.
• W2944014003 cites W2799378760 @default.
• W2944014003 cites W2891645969 @default.
• W2944014003 doi "https://doi.org/10.1016/j.actbio.2019.05.008" @default.
• W2944014003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31078764" @default.
• W2944014003 hasPublicationYear "2019" @default.
• W2944014003 type Work @default.
• W2944014003 sameAs 2944014003 @default.
• W2944014003 citedByCount "76" @default.
• W2944014003 countsByYear W29440140032019 @default.
• W2944014003 countsByYear W29440140032020 @default.
• W2944014003 countsByYear W29440140032021 @default.
• W2944014003 countsByYear W29440140032022 @default.
• W2944014003 countsByYear W29440140032023 @default.
• W2944014003 crossrefType "journal-article" @default.
• W2944014003 hasAuthorship W2944014003A5002187196 @default.
• W2944014003 hasAuthorship W2944014003A5005186305 @default.
• W2944014003 hasAuthorship W2944014003A5013038112 @default.
• W2944014003 hasAuthorship W2944014003A5041105225 @default.
• W2944014003 hasAuthorship W2944014003A5047932271 @default.
• W2944014003 hasAuthorship W2944014003A5062871251 @default.
• W2944014003 hasAuthorship W2944014003A5064323494 @default.
• W2944014003 hasAuthorship W2944014003A5078835329 @default.
• W2944014003 hasAuthorship W2944014003A5082012643 @default.
• W2944014003 hasAuthorship W2944014003A5086013055 @default.
• W2944014003 hasConcept C10138342 @default.
• W2944014003 hasConcept C108215921 @default.
• W2944014003 hasConcept C162324750 @default.
• W2944014003 hasConcept C171250308 @default.
• W2944014003 hasConcept C178790620 @default.
• W2944014003 hasConcept C18150654 @default.
• W2944014003 hasConcept C185592680 @default.
• W2944014003 hasConcept C192562407 @default.
• W2944014003 hasConcept C2776964284 @default.
• W2944014003 hasConcept C2779149719 @default.
• W2944014003 hasConcept C2779820397 @default.
• W2944014003 hasConcept C2781323092 @default.
• W2944014003 hasConcept C2781469039 @default.
• W2944014003 hasConcept C48349386 @default.
• W2944014003 hasConcept C54400483 @default.
• W2944014003 hasConcept C55493867 @default.
• W2944014003 hasConcept C75473681 @default.
• W2944014003 hasConceptScore W2944014003C10138342 @default.
• W2944014003 hasConceptScore W2944014003C108215921 @default.
• W2944014003 hasConceptScore W2944014003C162324750 @default.
• W2944014003 hasConceptScore W2944014003C171250308 @default.
• W2944014003 hasConceptScore W2944014003C178790620 @default.
• W2944014003 hasConceptScore W2944014003C18150654 @default.
• W2944014003 hasConceptScore W2944014003C185592680 @default.
• W2944014003 hasConceptScore W2944014003C192562407 @default.
• W2944014003 hasConceptScore W2944014003C2776964284 @default.
• W2944014003 hasConceptScore W2944014003C2779149719 @default.
• W2944014003 hasConceptScore W2944014003C2779820397 @default.
• W2944014003 hasConceptScore W2944014003C2781323092 @default.
• W2944014003 hasConceptScore W2944014003C2781469039 @default.
• W2944014003 hasConceptScore W2944014003C48349386 @default.
• W2944014003 hasConceptScore W2944014003C54400483 @default.
• W2944014003 hasConceptScore W2944014003C55493867 @default.

• next