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• W2944023461 abstract "Neural progenitor cells (NPCs) undergo rapid proliferation during neurulation. This rapid growth generates a high demand for mRNA translation in a timing-dependent manner, but its underlying mechanism remains poorly understood. Lin28 is an RNA-binding protein with two paralogs, Lin28a and Lin28b, in mammals. Mice with Lin28b deletion exhibit no developmental defects, whereas we previously reported that Lin28a deletion led to microcephaly. Here we found that Lin28a/b double knockout (dKO) mice displayed neural tube defects (NTDs) coupled with reduced proliferation and precocious differentiation of NPCs. Using ribosomal protein 24 hypomorphic mice (Rpl24Bst/+) as a genetic tool to dampen global protein synthesis, we found that Lin28a−/−;Rpl24Bst/+ compound mutants exhibited NTDs resembling those seen in Lin28a/b dKO mice. Increased NPC numbers and brain sizes in Lin28a-overexpressing mice were rescued by Rpl24Bst/+ heterozygosity. Mechanistically, polysome profiling revealed reduced translation of genes involved in the regulation of cell cycle, ribosome biogenesis, and translation in dKO mutants. Ribosome biogenesis was reduced in dKO and increased in Lin28a-overexpressing NPCs. Therefore, Lin28-mediated promotion of protein synthesis is essential for NPC maintenance and early brain development." @default.
• W2944023461 created "2019-05-16" @default.
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• W2944023461 date "2019-01-01" @default.
• W2944023461 modified "2023-10-03" @default.
• W2944023461 title "Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice" @default.
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• W2944023461 doi "https://doi.org/10.1242/dev.173765" @default.
• W2944023461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6550015" @default.
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• W2944023461 hasPublicationYear "2019" @default.
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