Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944070070> ?p ?o ?g. }
- W2944070070 endingPage "28" @default.
- W2944070070 startingPage "15" @default.
- W2944070070 abstract "Children with epilepsy and normal structural MRI pose a particular challenge in localization of epileptic foci for surgical resection. Many of these patients have subtle structural lesions such as mild cortical dysplasia that can be missed by conventional MRI but may become detectable by optimized and advanced MRI acquisitions and post-processing. Specificity of objective analytic techniques such as voxel-based morphometry remains an issue. Combination of MRI with functional imaging approaches can improve the accuracy of detecting epileptogenic brain regions. Analysis of glucose positron emission tomography (PET) combined with high-resolution MRI can optimize detection of hypometabolic cortex associated with subtle cortical malformations and can also enhance presurgical evaluation in children with epileptic spasms. Additional PET tracers may detect subtle epileptogenic lesions and cortex with enhanced specificity in carefully selected subgroups with various etiologies; e.g., increased tryptophan uptake can identify epileptogenic cortical dysplasia in the interictal state. Subtraction ictal SPECT can be also useful to delineate ictal foci in those with non-localizing PET or after failed surgical resection. Presurgical delineation of language and motor cortex and the corresponding white matter tracts is increasingly reliable by functional MRI and DTI techniques; with careful preparation, these can be useful even in young and sedated children. While evidence-based pediatric guidelines are still lacking, the data accumulated in the last decade strongly indicate that multimodal imaging with combined analysis of MRI, PET, and/or ictal SPECT data can optimize the detection of subtle epileptogenic lesions and facilitate seizure-free outcome while minimizing the postsurgical functional deficit in children with normal conventional MRI." @default.
- W2944070070 created "2019-05-16" @default.
- W2944070070 creator A5021942648 @default.
- W2944070070 creator A5065292346 @default.
- W2944070070 date "2020-04-01" @default.
- W2944070070 modified "2023-10-10" @default.
- W2944070070 title "Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy" @default.
- W2944070070 cites W1148140151 @default.
- W2944070070 cites W1479704859 @default.
- W2944070070 cites W1483189311 @default.
- W2944070070 cites W1503412826 @default.
- W2944070070 cites W1554092919 @default.
- W2944070070 cites W1591764851 @default.
- W2944070070 cites W1745904285 @default.
- W2944070070 cites W1785829893 @default.
- W2944070070 cites W1913911605 @default.
- W2944070070 cites W1964011929 @default.
- W2944070070 cites W1970854215 @default.
- W2944070070 cites W1972845142 @default.
- W2944070070 cites W1977752791 @default.
- W2944070070 cites W1979993702 @default.
- W2944070070 cites W1981685105 @default.
- W2944070070 cites W1981962537 @default.
- W2944070070 cites W1983356261 @default.
- W2944070070 cites W1985352547 @default.
- W2944070070 cites W1985638627 @default.
- W2944070070 cites W1985716571 @default.
- W2944070070 cites W1986874860 @default.
- W2944070070 cites W1986958163 @default.
- W2944070070 cites W1989355184 @default.
- W2944070070 cites W1991720707 @default.
- W2944070070 cites W1993235513 @default.
- W2944070070 cites W1994882224 @default.
- W2944070070 cites W1995743068 @default.
- W2944070070 cites W1996375631 @default.
- W2944070070 cites W1996454733 @default.
- W2944070070 cites W2003461749 @default.
- W2944070070 cites W2004521349 @default.
- W2944070070 cites W2010603840 @default.
- W2944070070 cites W2011314789 @default.
- W2944070070 cites W2011757669 @default.
- W2944070070 cites W2012780654 @default.
- W2944070070 cites W2015307941 @default.
- W2944070070 cites W2015370767 @default.
- W2944070070 cites W2016418015 @default.
- W2944070070 cites W2016444088 @default.
- W2944070070 cites W2019820648 @default.
- W2944070070 cites W2021198713 @default.
- W2944070070 cites W2021347723 @default.
- W2944070070 cites W2022783826 @default.
- W2944070070 cites W2025201822 @default.
- W2944070070 cites W2025230617 @default.
- W2944070070 cites W2030539449 @default.
- W2944070070 cites W2030841299 @default.
- W2944070070 cites W2033548518 @default.
- W2944070070 cites W2037752712 @default.
- W2944070070 cites W2041726742 @default.
- W2944070070 cites W2043158507 @default.
- W2944070070 cites W2043576412 @default.
- W2944070070 cites W2046146741 @default.
- W2944070070 cites W2046217280 @default.
- W2944070070 cites W2047277548 @default.
- W2944070070 cites W2047449825 @default.
- W2944070070 cites W2047596976 @default.
- W2944070070 cites W2051194546 @default.
- W2944070070 cites W2052451375 @default.
- W2944070070 cites W2055249364 @default.
- W2944070070 cites W2057452693 @default.
- W2944070070 cites W2059060097 @default.
- W2944070070 cites W2062437783 @default.
- W2944070070 cites W2065464671 @default.
- W2944070070 cites W2067749711 @default.
- W2944070070 cites W2073514374 @default.
- W2944070070 cites W2074904157 @default.
- W2944070070 cites W2077078512 @default.
- W2944070070 cites W2077438821 @default.
- W2944070070 cites W2079750246 @default.
- W2944070070 cites W2080198834 @default.
- W2944070070 cites W2080790127 @default.
- W2944070070 cites W2081567050 @default.
- W2944070070 cites W2081962670 @default.
- W2944070070 cites W2083140558 @default.
- W2944070070 cites W2085257111 @default.
- W2944070070 cites W2085476870 @default.
- W2944070070 cites W2086071028 @default.
- W2944070070 cites W2087433749 @default.
- W2944070070 cites W2088756903 @default.
- W2944070070 cites W2089970255 @default.
- W2944070070 cites W2101067729 @default.
- W2944070070 cites W2101801686 @default.
- W2944070070 cites W2103642624 @default.
- W2944070070 cites W2105653339 @default.
- W2944070070 cites W2108530756 @default.
- W2944070070 cites W2109617833 @default.
- W2944070070 cites W2110536017 @default.
- W2944070070 cites W2116146879 @default.
- W2944070070 cites W2120095497 @default.
- W2944070070 cites W2120274951 @default.