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- W2944072008 abstract "Abstract During pathogenesis, viruses hijack the host cellular machinery to access molecules and sub-cellular structures needed for infection. We have evidence that the multifunctional viral translation transactivator/viroplasmin (TAV) protein from Cauliflower mosaic virus (CaMV) can function as a suppressor of nonsense-mediated mRNA decay (NMD). TAV interacts specifically with a scaffold protein of the decapping complex VARICOSE (VCS) in the yeast two-hybrid system, and co-localizes with components of the decapping complex in planta. Notably, plants transgenic for TAV accumulate endogenous NMD-elicited mRNAs, while decay of AU-rich instability element (ARE)-signal containing mRNAs are not affected. Using an agroinfiltration-based transient assay we confirmed that TAV specifically stabilizes mRNA containing a premature termination codon (PTC) in a VCS-dependent manner. We have identified a TAV motif consisting of 12 of the 520 amino acids in the full-length sequence that is critical for both VCS binding and the NMD suppression effect. Our data suggest that TAV can intercept NMD by targeting the decapping machinery through the scaffold protein VARICOSE, indicating that 5′-3′ mRNA decapping is a late step in NMD-related mRNA degradation in plants." @default.
- W2944072008 created "2019-05-16" @default.
- W2944072008 creator A5031207646 @default.
- W2944072008 creator A5066844179 @default.
- W2944072008 date "2019-05-07" @default.
- W2944072008 modified "2023-10-18" @default.
- W2944072008 title "Cauliflower mosaic virus transactivator protein (TAV) can suppress nonsense-mediated decay by targeting VARICOSE, a scaffold protein of the decapping complex" @default.
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- W2944072008 doi "https://doi.org/10.1038/s41598-019-43414-0" @default.
- W2944072008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6504953" @default.
- W2944072008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31065034" @default.
- W2944072008 hasPublicationYear "2019" @default.
- W2944072008 type Work @default.