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- W2944076735 abstract "Although greater than 90% of breast cancer-related mortality can be attributed to metastases, the molecular mechanisms underpinning the dissemination of primary breast tumor cells and their ability to establish malignant lesions in distant tissues remain incompletely understood. Genomic and transcriptomic analyses identified a class of transcripts called long noncoding RNA (lncRNA), which interact both directly and indirectly with key components of gene regulatory networks to alter cell proliferation, invasion, and metastasis. We identified a pro-metastatic lncRNA BORG whose aberrant expression promotes metastatic relapse by reactivating proliferative programs in dormant disseminated tumor cells (DTCs). BORG expression is broadly and strongly induced by environmental and chemotherapeutic stresses, a transcriptional response that facilitates the survival of DTCs. Transcriptomic reprogramming in response to BORG resulted in robust signaling via survival and viability pathways, as well as decreased activation of cell death pathways. As such, BORG expression acts as a (i) marker capable of predicting which breast cancer patients are predisposed to develop secondary metastatic lesions, and (ii) unique therapeutic target to maximize chemosensitivity of DTCs. Here we review the molecular and cellular factors that contribute to the pathophysiological activities of BORG during its regulation of breast cancer metastasis, chemoresistance, and disease recurrence." @default.
- W2944076735 created "2019-05-16" @default.
- W2944076735 creator A5009610277 @default.
- W2944076735 creator A5030509324 @default.
- W2944076735 creator A5048754135 @default.
- W2944076735 creator A5090145675 @default.
- W2944076735 date "2019-05-10" @default.
- W2944076735 modified "2023-10-17" @default.
- W2944076735 title "The lncRNA BORG: a novel inducer of TNBC metastasis, chemoresistance, and disease recurrence" @default.
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