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- W2944165660 abstract "Background: Childhood maltreatment increases the risk of suicide attempts in the general population, possibly having similar effects among patients with major depressive disorder (MDD). The few studies that have addressed this association have been restricted to specific populations (e.g. treatment-resistant depression, personality disorders) and have rarely taken sex into account. Objective: To examine the impact of childhood maltreatment on suicide attempts among MDD patients above and beyond other risk factors and potential confounders, while considering potential sex-specific effects. Methods: The study assessed 165 patients with a principal diagnosis of MDD. Neurological alterations, psychiatric comorbidities, and drug abuse were reasons for exclusion. Logistic regressions using the whole sample, and divided by sex, were run to test the association between childhood maltreatment and history of suicide attempts, controlling for symptom severity, comorbidities, and treatment-resistant depression. Results: There was a significant and clinically relevant association between childhood maltreatment and history of suicide attempts in the total sample. Patients with childhood maltreatment were 3.01 times more likely to present a history of suicide attempts than patients without childhood maltreatment. A family history of psychiatric disorders also contributed to the variance of attempted suicide, but its interaction with childhood maltreatment was not statistically significant. When testing the model separately, the effect of childhood maltreatment on suicide attempts remained for females, whereas for males, age of MDD onset and Childhood Trauma Questionnaire minimization-denial scale were predictive variables. Conclusions: Childhood maltreatment is a clear predictor of suicidal behaviour among MDD patients, and this effect remains significant after controlling for potential confounders. Also, the sex of patients emerges as a relevant factor that may model the mechanisms underlying the prediction of suicide attempts. Since suicide is the main cause of premature death among MDD patients, interventions targeting childhood maltreatment should be included in preventive and clinical strategies.Planteamiento: el maltrato infantil aumenta el riesgo de intentos de suicidio en la población general, y podría tener efectos similares en pacientes con trastorno depresivo mayor (TDM). Los escasos estudios que han abordado este tema se han restringido a poblaciones específicas (p.ej. depresión resistente al tratamiento, trastornos de personalidad) y rara vez tienen en cuenta el sexo.Objetivo: evaluar el impacto del maltrato infantil en las tentativas de suicidio en pacientes con TDM, considerando potenciales factores de riesgo y de confusión, al tiempo que se estudian los posibles efectos del sexo.Método: se evaluó una muestra de 165 pacientes con diagnóstico principal de TDM. Las alteraciones neurológicas, las comorbilidades psiquiátricas y el abuso de drogas fueron motivos de exclusión. Para explorar la asociación entre el maltrato infantil y el historial de intentos de suicidio (controlando por la gravedad de los síntomas, la comorbilidad y la resistencia al tratamiento), se realizaron regresiones logísticas con la muestra completa, así como en hombres y mujeres por separado.Resultados: existe una asociación significativa y clínicamente relevante entre el maltrato infantil y la historia de intentos de suicidio en el total de la muestra. Las personas con maltrato infantil tenían 3,01 veces más probabilidades de presentar historia de tentativas de suicidio que aquellas sin maltrato infantil. Los antecedentes familiares de trastorno psiquiátrico también contribuyeron a la varianza de los intentos de suicidio, pero su interacción con el maltrato infantil no resultó estadísticamente significativa. Al analizar el modelo por separado, el efecto del maltrato infantil en las tentativas suicidas se mantuvo en las pacientes mujeres, mientras que en los pacientes hombres la edad de inicio del TDM y la escala de minimización-negación del CTQ fueron las variables explicativas.Conclusiones: el maltrato infantil predice el comportamiento suicida en pacientes con TDM, persistiendo este efecto después de controlar posibles factores de confusión. Además, el sexo de las personas modelaría los mecanismos subyacentes en cuanto a predecir las tentativas de suicidio. Dado que el suicidio es la principal causa de muerte prematura entre pacientes con TDM, las intervenciones dirigidas al maltrato infantil deberían incluirse dentro de las estrategias tanto preventivas como terapéuticas.背景:在一般人群中,童年虐待会增加自杀的风险。在患有严重抑郁症(MDD)的病人群体中可能有相似的关联。少数研究讨论这种关联的研究仅限于特定人群(即治疗抵抗性抑郁症,人格障碍),并且很少考虑到性别。目的:在其他风险因素和潜在混淆因素之外,研究儿童虐待对MDD患者自杀企图的影响,同时考虑性别的潜在影响。方法:对165例诊断为MDD的患者进行评估,排除神经系统改变、精神病合并症和药物滥用。对整个样本进行逻辑回归分析,控制了症状的严重程度、合并症和难治性抑郁症后,区分不同性别,考察儿童期虐待和自杀企图历史之间的关联。结果:结果显示,童年虐待与总样本中自杀未遂史之间具有显著的临床相关性。与没有儿童期虐待的患者相比,患有儿童期虐待的患者自杀未遂史的可能性是3.01倍。精神疾病的家族史也导致了自杀未遂的变异,但其与儿童期虐待的相互作用在统计学上并不显著。当分性别考察时,童年虐待对自杀未遂的影响在女性依然存在,而男性中MDD发病年龄和CTQ最小化-否认量表(minimization-denial scale)是预测变量。结论:童年虐待是MDD患者自杀行为的明确预测因素,在控制潜在混淆因素后,这种影响仍然很明显。此外,患者性别是可以预测自杀未遂的机制的一个相关因素。鉴于自杀是MDD患者早亡的主要原因,针对儿童期虐待的干预措施应纳入预防和临床方案。." @default.
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- W2944165660 date "2019-05-07" @default.
- W2944165660 modified "2023-10-18" @default.
- W2944165660 title "Childhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach" @default.
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- W2944165660 doi "https://doi.org/10.1080/20008198.2019.1603557" @default.
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