Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944170821> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2944170821 abstract "Introduction Barrett’s oesophagus (BO) is the only known precursor of esophageal adenocarcinoma. The current gold-standard test for diagnosing BO is endoscopy which is expensive and impractical as a population screening tool. We aimed to develop a robust questionnaire that could be used in routine clinical practice to identify patients with different likelihoods of having BO. Methods We retrospectively analyzed data from two independent prospective datasets: BEST2 and BOOST case-control studies with 1299 and 398 patients, respectively. The BEST2 dataset was split into testing (n=776) and independent validation (n=523) cohorts. Using machine learning techniques (information gain and correlation-based feature selection followed by logistic regression); we identified panels of markers which predicted the presence of BO and then cross validated them between the datasets in order to create a robust set of markers that could be used for future studies. Results Panels comprising the same thirteen demographic and patient symptom features predicted the occurrence of BO in both datasets. These included three demographic features (age, gender and ethnicity), three general patient characteristics (weight, waist circumference, quantity of cigarettes smoked), and six symptoms (years since heartburn and acid taste developed, frequency of heartburn, acid taste symptoms, chest pain and taking stomach medicines). Although there were minor variations in logistic weights for each feature between the panels, they yielded accuracies with areas under the curve (AUC) of 0.91 in the BEST2 and 0.84 in the BOOST cohorts. Furthermore, despite differences in population composition, the panels validated across datasets. Validating the BEST2 model with BOOST yielded a ROC curve of 0.83 and validating the BOOST model against BEST2 yielded a ROC curve of 0.91. The final panel was also validated with the external BEST2 validation cohort (n=523) with AUC = 0.91 (table 1). Conclusions This study identifies thirteen markers as a potential method for non-invasive screening for BO. These markers are consistent across different patient study groups. The panel needs to be validated in a prospective study." @default.
- W2944170821 created "2019-05-16" @default.
- W2944170821 creator A5007030080 @default.
- W2944170821 creator A5011340913 @default.
- W2944170821 creator A5017844877 @default.
- W2944170821 creator A5024116636 @default.
- W2944170821 creator A5030008266 @default.
- W2944170821 creator A5036726782 @default.
- W2944170821 creator A5042843181 @default.
- W2944170821 creator A5044467644 @default.
- W2944170821 creator A5045327103 @default.
- W2944170821 creator A5050185056 @default.
- W2944170821 creator A5051589747 @default.
- W2944170821 creator A5054758976 @default.
- W2944170821 creator A5060644314 @default.
- W2944170821 creator A5066997562 @default.
- W2944170821 creator A5075497113 @default.
- W2944170821 creator A5088931272 @default.
- W2944170821 date "2019-06-01" @default.
- W2944170821 modified "2023-10-18" @default.
- W2944170821 title "OTU-16 A machine learning-based model to predict the presence of barrett’s oesophagus" @default.
- W2944170821 doi "https://doi.org/10.1136/gutjnl-2019-bsgabstracts.251" @default.
- W2944170821 hasPublicationYear "2019" @default.
- W2944170821 type Work @default.
- W2944170821 sameAs 2944170821 @default.
- W2944170821 citedByCount "0" @default.
- W2944170821 crossrefType "proceedings-article" @default.
- W2944170821 hasAuthorship W2944170821A5007030080 @default.
- W2944170821 hasAuthorship W2944170821A5011340913 @default.
- W2944170821 hasAuthorship W2944170821A5017844877 @default.
- W2944170821 hasAuthorship W2944170821A5024116636 @default.
- W2944170821 hasAuthorship W2944170821A5030008266 @default.
- W2944170821 hasAuthorship W2944170821A5036726782 @default.
- W2944170821 hasAuthorship W2944170821A5042843181 @default.
- W2944170821 hasAuthorship W2944170821A5044467644 @default.
- W2944170821 hasAuthorship W2944170821A5045327103 @default.
- W2944170821 hasAuthorship W2944170821A5050185056 @default.
- W2944170821 hasAuthorship W2944170821A5051589747 @default.
- W2944170821 hasAuthorship W2944170821A5054758976 @default.
- W2944170821 hasAuthorship W2944170821A5060644314 @default.
- W2944170821 hasAuthorship W2944170821A5066997562 @default.
- W2944170821 hasAuthorship W2944170821A5075497113 @default.
- W2944170821 hasAuthorship W2944170821A5088931272 @default.
- W2944170821 hasBestOaLocation W29441708211 @default.
- W2944170821 hasConcept C126322002 @default.
- W2944170821 hasConcept C138885662 @default.
- W2944170821 hasConcept C148483581 @default.
- W2944170821 hasConcept C151956035 @default.
- W2944170821 hasConcept C154945302 @default.
- W2944170821 hasConcept C170964787 @default.
- W2944170821 hasConcept C2776193436 @default.
- W2944170821 hasConcept C2776401178 @default.
- W2944170821 hasConcept C2776462128 @default.
- W2944170821 hasConcept C2779134260 @default.
- W2944170821 hasConcept C2780221984 @default.
- W2944170821 hasConcept C2908647359 @default.
- W2944170821 hasConcept C40993552 @default.
- W2944170821 hasConcept C41008148 @default.
- W2944170821 hasConcept C41895202 @default.
- W2944170821 hasConcept C43270747 @default.
- W2944170821 hasConcept C71924100 @default.
- W2944170821 hasConcept C99454951 @default.
- W2944170821 hasConceptScore W2944170821C126322002 @default.
- W2944170821 hasConceptScore W2944170821C138885662 @default.
- W2944170821 hasConceptScore W2944170821C148483581 @default.
- W2944170821 hasConceptScore W2944170821C151956035 @default.
- W2944170821 hasConceptScore W2944170821C154945302 @default.
- W2944170821 hasConceptScore W2944170821C170964787 @default.
- W2944170821 hasConceptScore W2944170821C2776193436 @default.
- W2944170821 hasConceptScore W2944170821C2776401178 @default.
- W2944170821 hasConceptScore W2944170821C2776462128 @default.
- W2944170821 hasConceptScore W2944170821C2779134260 @default.
- W2944170821 hasConceptScore W2944170821C2780221984 @default.
- W2944170821 hasConceptScore W2944170821C2908647359 @default.
- W2944170821 hasConceptScore W2944170821C40993552 @default.
- W2944170821 hasConceptScore W2944170821C41008148 @default.
- W2944170821 hasConceptScore W2944170821C41895202 @default.
- W2944170821 hasConceptScore W2944170821C43270747 @default.
- W2944170821 hasConceptScore W2944170821C71924100 @default.
- W2944170821 hasConceptScore W2944170821C99454951 @default.
- W2944170821 hasLocation W29441708211 @default.
- W2944170821 hasOpenAccess W2944170821 @default.
- W2944170821 hasPrimaryLocation W29441708211 @default.
- W2944170821 hasRelatedWork W1036465 @default.
- W2944170821 hasRelatedWork W10510644 @default.
- W2944170821 hasRelatedWork W10977650 @default.
- W2944170821 hasRelatedWork W12145150 @default.
- W2944170821 hasRelatedWork W1345230 @default.
- W2944170821 hasRelatedWork W15922944 @default.
- W2944170821 hasRelatedWork W3568817 @default.
- W2944170821 hasRelatedWork W5512120 @default.
- W2944170821 hasRelatedWork W6037433 @default.
- W2944170821 hasRelatedWork W8848618 @default.
- W2944170821 isParatext "false" @default.
- W2944170821 isRetracted "false" @default.
- W2944170821 magId "2944170821" @default.
- W2944170821 workType "article" @default.