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- W2944172334 abstract "Background: Sea anemones are toxic sedentary invertebrates that are often present in the intertidal zone. Objectives: In this study, cytotoxic effects of the crude extract and its fractions from the oral disk of Stichodactyla haddoni on breast cancer cell line MCF-7 were investigated. Methods: Samples were collected from the intertidal zone in the Persian Gulf. Phosphate buffer saline (PBS) and Millipore filters were used to prepare the crude extract and its fractions, respectively. MCF-7 cells were exposed to the crude extract or one of its five fractions, (with molecular weights < 3 kDa to > 100 kDa) at concentrations of 200 to 1400 μg/mL for 24 to 48 hours. Results: All treatments inhibited the growth of MCF-7 cancer cells. The highest inhibitory effect belonged to fractions 2 and 5, with 85 and 81.3% lethality, respectively. These fractions with the concentration of 1200 and 1400 μg/mL had the most anticancer effects against MCF-7. Conclusions: The 1200 μg/mL concentration of fraction 5 containing peptides < 3 kDa is recommended for separation and purification of its components for pharmacological studies to control breast cancer." @default.
- W2944172334 created "2019-05-16" @default.
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- W2944172334 date "2019-05-11" @default.
- W2944172334 modified "2023-09-26" @default.
- W2944172334 title "Inhibitory Effects of Crude and Filtered Extracts from Oral Disk of Sea Anemone (Stichodactyla haddoni) on MCF-7 Cell Line" @default.
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- W2944172334 doi "https://doi.org/10.5812/jjnpp.65799" @default.
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