FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944172358> ?p ?o ?g. }

• W2944172358 endingPage "404" @default.
• W2944172358 startingPage "394" @default.
• W2944172358 abstract "Cerebral oedema is a major pathological change of acute carbon monoxide (CO) poisoning, the pathogenesis of which is still unclear. In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral oedema of various neuropathological events. However, their functions in CO poisoning have not been demonstrated. In this study, we investigated the expressions of AQPs and associated mechanisms of brain injury in an acute CO poisoning rat model. Compared with the control injected intraperitoneally with equal volume of air, the dry weight/wet weight (DW/WW) ratio of brain water content, levels of AQP1, AQP4, phosph-p38 mitogen-activated protein kinase (p-p38 MAPK) and astrocyte marker, glial fibrillary acidic protein (GFAP) in the frontal cortex and hippocampal CA1 of acute CO poisoning group significantly increased at 6, 12, 24 hours after CO injection. Intracerebroventricular injection with a p38 MAPK inhibitor, SB203580 (200 µmol/L/kg/d), before CO injection reduced water content in the brain tissues and significantly decreased levels of AQP1, AQP4, p-p38 MAPK and GFAP. Therefore, our study showed that the overexpressions of AQP1 and AQP4 were involved in the development of CO poisoning-induced cerebral oedema, which could be attenuated by inhibition of p-p38 MAPK signalling. Manipulation of AQPs and p38 MAPK may be a new therapeutic strategy for acute CO poisoning." @default.
• W2944172358 created "2019-05-16" @default.
• W2944172358 creator A5013440540 @default.
• W2944172358 creator A5018135592 @default.
• W2944172358 creator A5020742587 @default.
• W2944172358 creator A5034424106 @default.
• W2944172358 creator A5038145110 @default.
• W2944172358 creator A5038302775 @default.
• W2944172358 creator A5039881345 @default.
• W2944172358 creator A5040765198 @default.
• W2944172358 creator A5040847661 @default.
• W2944172358 creator A5057066988 @default.
• W2944172358 date "2019-06-03" @default.
• W2944172358 modified "2023-09-24" @default.
• W2944172358 title "Involvement of p38 mitogen‐activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes" @default.
• W2944172358 cites W1026160706 @default.
• W2944172358 cites W12166679 @default.
• W2944172358 cites W1479913563 @default.
• W2944172358 cites W1495656315 @default.
• W2944172358 cites W1578750681 @default.
• W2944172358 cites W1728301756 @default.
• W2944172358 cites W178899771 @default.
• W2944172358 cites W1867040256 @default.
• W2944172358 cites W1970990142 @default.
• W2944172358 cites W1993847383 @default.
• W2944172358 cites W1998196587 @default.
• W2944172358 cites W2001610623 @default.
• W2944172358 cites W2006157741 @default.
• W2944172358 cites W2006740852 @default.
• W2944172358 cites W2007028158 @default.
• W2944172358 cites W2018534508 @default.
• W2944172358 cites W2020410632 @default.
• W2944172358 cites W2021036163 @default.
• W2944172358 cites W2031945440 @default.
• W2944172358 cites W2045237954 @default.
• W2944172358 cites W2045426130 @default.
• W2944172358 cites W2049605112 @default.
• W2944172358 cites W2050462141 @default.
• W2944172358 cites W2051530309 @default.
• W2944172358 cites W2060701169 @default.
• W2944172358 cites W2060802422 @default.
• W2944172358 cites W2063559846 @default.
• W2944172358 cites W2067517471 @default.
• W2944172358 cites W2069085932 @default.
• W2944172358 cites W2072251236 @default.
• W2944172358 cites W2089581014 @default.
• W2944172358 cites W2095638157 @default.
• W2944172358 cites W2105443363 @default.
• W2944172358 cites W2106090635 @default.
• W2944172358 cites W2110069095 @default.
• W2944172358 cites W2134781293 @default.
• W2944172358 cites W2137653998 @default.
• W2944172358 cites W2178864453 @default.
• W2944172358 cites W2278297567 @default.
• W2944172358 cites W2291424342 @default.
• W2944172358 cites W2332950985 @default.
• W2944172358 cites W2474038480 @default.
• W2944172358 cites W2527238660 @default.
• W2944172358 cites W2532034722 @default.
• W2944172358 cites W2583758651 @default.
• W2944172358 cites W2597448453 @default.
• W2944172358 cites W2608626412 @default.
• W2944172358 cites W2809064859 @default.
• W2944172358 cites W562487747 @default.
• W2944172358 doi "https://doi.org/10.1111/bcpt.13247" @default.
• W2944172358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31063681" @default.
• W2944172358 hasPublicationYear "2019" @default.
• W2944172358 type Work @default.
• W2944172358 sameAs 2944172358 @default.
• W2944172358 citedByCount "9" @default.
• W2944172358 countsByYear W29441723582020 @default.
• W2944172358 countsByYear W29441723582021 @default.
• W2944172358 countsByYear W29441723582022 @default.
• W2944172358 countsByYear W29441723582023 @default.
• W2944172358 crossrefType "journal-article" @default.
• W2944172358 hasAuthorship W2944172358A5013440540 @default.
• W2944172358 hasAuthorship W2944172358A5018135592 @default.
• W2944172358 hasAuthorship W2944172358A5020742587 @default.
• W2944172358 hasAuthorship W2944172358A5034424106 @default.
• W2944172358 hasAuthorship W2944172358A5038145110 @default.
• W2944172358 hasAuthorship W2944172358A5038302775 @default.
• W2944172358 hasAuthorship W2944172358A5039881345 @default.
• W2944172358 hasAuthorship W2944172358A5040765198 @default.
• W2944172358 hasAuthorship W2944172358A5040847661 @default.
• W2944172358 hasAuthorship W2944172358A5057066988 @default.
• W2944172358 hasBestOaLocation W29441723581 @default.
• W2944172358 hasConcept C126322002 @default.
• W2944172358 hasConcept C134018914 @default.
• W2944172358 hasConcept C148762608 @default.
• W2944172358 hasConcept C15755913 @default.
• W2944172358 hasConcept C184235292 @default.
• W2944172358 hasConcept C185592680 @default.
• W2944172358 hasConcept C204232928 @default.
• W2944172358 hasConcept C2777542381 @default.
• W2944172358 hasConcept C2780495277 @default.
• W2944172358 hasConcept C51551487 @default.
• W2944172358 hasConcept C529278444 @default.
• W2944172358 hasConcept C55493867 @default.

• next