Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944200073> ?p ?o ?g. }
- W2944200073 startingPage "635730" @default.
- W2944200073 abstract "Abstract An unmet clinical need in solid tumor cancers is the ability to harness the intrinsic spatial information in primary tumors that can be exploited to optimize prognostics, diagnostics and therapeutic strategies for precision medicine. We have developed a transformational spatial analytics (SpAn) computational and systems biology platform that predicts clinical outcomes and captures emergent spatial biology that can potentially inform therapeutic strategies. Here we apply SpAn to primary tumor tissue samples from a cohort of 432 chemo-naive colorectal cancer (CRC) patients iteratively labeled with a highly multiplexed (hyperplexed) panel of fifty-five fluorescently tagged antibodies. SpAn predicted the 5-year risk of CRC recurrence with a mean area under the ROC curve of 88.5% (SE of 0.1%), significantly better than current state-of-the-art methods. SpAn also inferred the emergent network biology of the tumor spatial domains revealing a synergistic role of known features from CRC consensus molecular subtypes that will enhance precision medicine." @default.
- W2944200073 created "2019-05-16" @default.
- W2944200073 creator A5011496452 @default.
- W2944200073 creator A5020232306 @default.
- W2944200073 creator A5028183521 @default.
- W2944200073 creator A5040798509 @default.
- W2944200073 creator A5045609598 @default.
- W2944200073 creator A5046440469 @default.
- W2944200073 creator A5056586582 @default.
- W2944200073 creator A5071660155 @default.
- W2944200073 creator A5076728915 @default.
- W2944200073 creator A5081260142 @default.
- W2944200073 creator A5081552804 @default.
- W2944200073 date "2019-05-13" @default.
- W2944200073 modified "2023-09-27" @default.
- W2944200073 title "A spatial analytics computational and systems biology platform predicts risk of colorectal cancer recurrence and identifies emergent spatial domain networks associated with recurrence" @default.
- W2944200073 cites W1490956705 @default.
- W2944200073 cites W1507435475 @default.
- W2944200073 cites W1525899559 @default.
- W2944200073 cites W1573116352 @default.
- W2944200073 cites W1593419537 @default.
- W2944200073 cites W1934094702 @default.
- W2944200073 cites W1965498876 @default.
- W2944200073 cites W1970372358 @default.
- W2944200073 cites W1971078715 @default.
- W2944200073 cites W1972825083 @default.
- W2944200073 cites W1974478155 @default.
- W2944200073 cites W1976792842 @default.
- W2944200073 cites W1983533553 @default.
- W2944200073 cites W1985514943 @default.
- W2944200073 cites W1993396994 @default.
- W2944200073 cites W2011088911 @default.
- W2944200073 cites W2015255108 @default.
- W2944200073 cites W2020430786 @default.
- W2944200073 cites W2021733365 @default.
- W2944200073 cites W2022156993 @default.
- W2944200073 cites W2022169717 @default.
- W2944200073 cites W2036797607 @default.
- W2944200073 cites W2040467756 @default.
- W2944200073 cites W2042789810 @default.
- W2944200073 cites W2047332122 @default.
- W2944200073 cites W2049299149 @default.
- W2944200073 cites W2051369708 @default.
- W2944200073 cites W2057534419 @default.
- W2944200073 cites W2060012211 @default.
- W2944200073 cites W2069087118 @default.
- W2944200073 cites W2074454712 @default.
- W2944200073 cites W2078200937 @default.
- W2944200073 cites W2085653208 @default.
- W2944200073 cites W2093453499 @default.
- W2944200073 cites W2096731080 @default.
- W2944200073 cites W2097360283 @default.
- W2944200073 cites W2097554174 @default.
- W2944200073 cites W2099919979 @default.
- W2944200073 cites W2107894271 @default.
- W2944200073 cites W2111136847 @default.
- W2944200073 cites W2112143589 @default.
- W2944200073 cites W2113983227 @default.
- W2944200073 cites W2114319457 @default.
- W2944200073 cites W2115709314 @default.
- W2944200073 cites W2117692326 @default.
- W2944200073 cites W2119581553 @default.
- W2944200073 cites W2119938514 @default.
- W2944200073 cites W2122825543 @default.
- W2944200073 cites W2123664981 @default.
- W2944200073 cites W2125586870 @default.
- W2944200073 cites W2126537932 @default.
- W2944200073 cites W2129786622 @default.
- W2944200073 cites W2133773373 @default.
- W2944200073 cites W2141768150 @default.
- W2944200073 cites W2146950091 @default.
- W2944200073 cites W2148888894 @default.
- W2944200073 cites W2152064969 @default.
- W2944200073 cites W2152575748 @default.
- W2944200073 cites W2155688623 @default.
- W2944200073 cites W2157000380 @default.
- W2944200073 cites W2157076315 @default.
- W2944200073 cites W2158741313 @default.
- W2944200073 cites W2163206184 @default.
- W2944200073 cites W2167826316 @default.
- W2944200073 cites W2193047205 @default.
- W2944200073 cites W2193067168 @default.
- W2944200073 cites W2197045356 @default.
- W2944200073 cites W2266031367 @default.
- W2944200073 cites W2270126973 @default.
- W2944200073 cites W2318459925 @default.
- W2944200073 cites W2340482034 @default.
- W2944200073 cites W2342031461 @default.
- W2944200073 cites W2484537582 @default.
- W2944200073 cites W2527375200 @default.
- W2944200073 cites W2537623931 @default.
- W2944200073 cites W2540633756 @default.
- W2944200073 cites W2559987042 @default.
- W2944200073 cites W2569086487 @default.
- W2944200073 cites W2571903415 @default.
- W2944200073 cites W2577140298 @default.
- W2944200073 cites W2577155912 @default.
- W2944200073 cites W2580868502 @default.
- W2944200073 cites W2582393724 @default.