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- W2944290552 abstract "Three-dimensional matrices often contain highly structured adhesive tracks that require cells to turn corners and bridge non-adhesive areas. Here, we investigate these complex processes using micropatterned cell adhesive frames. Spreading kinetics on these matrices depend strongly on initial adhesive position and are predicted by a cellular Potts model (CPM), which reflects a balance between adhesion and intracellular tension. As cells spread, new stress fibers (SFs) assemble periodically and parallel to the leading edge, with spatial intervals of ∼2.5 μm, temporal intervals of ∼15 min, and characteristic lifetimes of ∼50 min. By incorporating these rules into the CPM, we can successfully predict SF network architecture. Moreover, we observe broadly similar behavior when we culture cells on arrays of discrete collagen fibers. Our findings show that ECM geometry and initial cell position strongly determine cell spreading and that cells encode a memory of their spreading history through SF network organization." @default.
- W2944290552 created "2019-05-16" @default.
- W2944290552 creator A5038613581 @default.
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- W2944290552 date "2019-05-01" @default.
- W2944290552 modified "2023-10-14" @default.
- W2944290552 title "Extracellular Matrix Geometry and Initial Adhesive Position Determine Stress Fiber Network Organization during Cell Spreading" @default.
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- W2944290552 doi "https://doi.org/10.1016/j.celrep.2019.04.035" @default.
- W2944290552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6530591" @default.
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- W2944290552 hasPublicationYear "2019" @default.
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