FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944290911> ?p ?o ?g. }

• W2944290911 abstract "Abstract The word ‘chiral’ is derived from the Greek word ‘cheir’, which means hand. Chiral molecules are molecules that are related to each other in the same way that a left hand is related to a right hand. These molecules are mirror images of each other and are nonsuperimposable. Chiral separations traditionally have been considered among the most difficult of all separations because enantiomers have identical chemical and physical properties in an achiral environment. In this article, we focus on techniques used in high‐performance liquid chromatography (HPLC). Most chiral separations by HPLC are accomplished via direct resolution using a chiral stationary phase (CSP). In this technique, a chiral resolving agent is bound or immobilized to an appropriate support to make a CSP, and the enantiomers are resolved by the formation of temporary diastereomeric complexes between the analyte and the CSP. Various types of CSPs have been developed, including polysaccharide‐based, cyclodextrin‐based, cyclofructan‐based, macrocyclic antibiotic‐based, protein‐based, Pirkle‐type, and ligand‐exchange CSPs. The most commercially common CSPs, polysaccharide‐based phases, consist of derivatized cellulose and amylose coated on silica gel and a new generation of polysaccharide‐based phases, which is immobilized through covalent bonding to a silica gel. Generally, analytes separated using the cyclodextrins require the formation of an inclusion complex between the analyte and the cyclodextrin. Separation is most favorable when the analyte also interacts with the mouth of the cyclodextrin molecule via hydrogen bonding to the functional groups present. The cyclofructan‐based CSPs are the newest development in chiral HPLC columns and are now available commercially. These bonded CSPs show excellent enantioselectivity toward all types of primary amines as well as other varieties of compounds. Numerous analytes have been separated using the macrocyclic antibiotic‐based CSPs, which can also be derivatized to alter their selectivity. Protein‐based CSPs comprise a number of commercially available columns. The protein‐based CSPs resemble the bonded macrocyclic antibiotic CSPs in many ways; however, the macrocyclic antibiotic CSPs are more stable and have greater capacities than the protein‐based CSPs. The Pirkle‐type CSPs typically use nonpolar organic mobile phases and often require derivatization of the analyte to add a π‐acid or π‐basic moiety, or both, to achieve separation. Ligand‐exchange phases are used with aqueous buffer mobile phases in which enantiomers are separated based on the differences in their charge and ionization constants. Limitations of ligand‐exchange separations are that only ionized analytes can be resolved using this technique and the copper‐salt‐containing mobile phases used absorb in the ultraviolet (UV) region, decreasing detection sensitivity." @default.
• W2944290911 created "2019-05-16" @default.
• W2944290911 creator A5029467235 @default.
• W2944290911 creator A5039798635 @default.
• W2944290911 date "2012-12-17" @default.
• W2944290911 modified "2023-10-01" @default.
• W2944290911 title "Chiral Separations by High‐Performance Liquid ChromatographyUpdate based on the original article by Timothy J. Ward and Tanya M. Oswald, <i>Encyclopedia of Analytical Chemistry</i> , © 2000, John Wiley & Sons, Ltd." @default.
• W2944290911 cites W146927540 @default.
• W2944290911 cites W1544538214 @default.
• W2944290911 cites W1551135345 @default.
• W2944290911 cites W1576740923 @default.
• W2944290911 cites W1964145469 @default.
• W2944290911 cites W1972122471 @default.
• W2944290911 cites W1973794502 @default.
• W2944290911 cites W1974569290 @default.
• W2944290911 cites W1984399806 @default.
• W2944290911 cites W1984717640 @default.
• W2944290911 cites W1990402526 @default.
• W2944290911 cites W1992404453 @default.
• W2944290911 cites W1993478010 @default.
• W2944290911 cites W1993597472 @default.
• W2944290911 cites W1994611536 @default.
• W2944290911 cites W1995096112 @default.
• W2944290911 cites W1998784110 @default.
• W2944290911 cites W1998897298 @default.
• W2944290911 cites W2000052098 @default.
• W2944290911 cites W2000751377 @default.
• W2944290911 cites W2003643111 @default.
• W2944290911 cites W2003731836 @default.
• W2944290911 cites W2004040714 @default.
• W2944290911 cites W2004070303 @default.
• W2944290911 cites W2004929427 @default.
• W2944290911 cites W2009205275 @default.
• W2944290911 cites W2011846673 @default.
• W2944290911 cites W2012968531 @default.
• W2944290911 cites W2013466196 @default.
• W2944290911 cites W2016539386 @default.
• W2944290911 cites W2018639457 @default.
• W2944290911 cites W2019613831 @default.
• W2944290911 cites W2020811912 @default.
• W2944290911 cites W2024373428 @default.
• W2944290911 cites W2025119425 @default.
• W2944290911 cites W2025759301 @default.
• W2944290911 cites W2031811416 @default.
• W2944290911 cites W2033766340 @default.
• W2944290911 cites W2034039208 @default.
• W2944290911 cites W2035063535 @default.
• W2944290911 cites W2035516477 @default.
• W2944290911 cites W2035901093 @default.
• W2944290911 cites W2036106040 @default.
• W2944290911 cites W2037744324 @default.
• W2944290911 cites W2038334243 @default.
• W2944290911 cites W2039933576 @default.
• W2944290911 cites W2040154890 @default.
• W2944290911 cites W2040524342 @default.
• W2944290911 cites W2046662068 @default.
• W2944290911 cites W2052921031 @default.
• W2944290911 cites W2052979010 @default.
• W2944290911 cites W2056267399 @default.
• W2944290911 cites W2058050316 @default.
• W2944290911 cites W2059419702 @default.
• W2944290911 cites W2060705457 @default.
• W2944290911 cites W2062505722 @default.
• W2944290911 cites W2063144677 @default.
• W2944290911 cites W2064773429 @default.
• W2944290911 cites W2065239428 @default.
• W2944290911 cites W2066608361 @default.
• W2944290911 cites W2067163909 @default.
• W2944290911 cites W2069763923 @default.
• W2944290911 cites W2070926360 @default.
• W2944290911 cites W2077928885 @default.
• W2944290911 cites W2081434926 @default.
• W2944290911 cites W2082287589 @default.
• W2944290911 cites W2084983500 @default.
• W2944290911 cites W2099085400 @default.
• W2944290911 cites W2108968366 @default.
• W2944290911 cites W2118913165 @default.
• W2944290911 cites W2124893526 @default.
• W2944290911 cites W2149523040 @default.
• W2944290911 cites W2159668063 @default.
• W2944290911 cites W2169796430 @default.
• W2944290911 cites W2314868168 @default.
• W2944290911 cites W2323703379 @default.
• W2944290911 cites W2331332755 @default.
• W2944290911 cites W2526994348 @default.
• W2944290911 cites W2584091758 @default.
• W2944290911 cites W3005245683 @default.
• W2944290911 cites W32399540 @default.
• W2944290911 cites W405538651 @default.
• W2944290911 cites W4245429107 @default.
• W2944290911 cites W4255236003 @default.
• W2944290911 cites W599283479 @default.
• W2944290911 doi "https://doi.org/10.1002/9780470027318.a5905.pub2" @default.
• W2944290911 hasPublicationYear "2012" @default.
• W2944290911 type Work @default.
• W2944290911 sameAs 2944290911 @default.
• W2944290911 citedByCount "1" @default.
• W2944290911 countsByYear W29442909112019 @default.
• W2944290911 crossrefType "other" @default.
• W2944290911 hasAuthorship W2944290911A5029467235 @default.

• next