FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944307347> ?p ?o ?g. }

• W2944307347 endingPage "526" @default.
• W2944307347 startingPage "519" @default.
• W2944307347 abstract "Background: Anal canal squamous cell carcinoma (SCC) is managed definitively with chemoradiation, reserving surgery for salvage. The dosage of radiation has varied from 30 Gy to in excess of 60 Gy. RTOG 0529 established intensity modulated radiation therapy (IMRT) as standard of care for anal canal SCC with doses of 50.4 to 54 Gy. We sought to use the National Cancer Database to examine trends in dose selection and radiation technique over time. Methods: We queried the National Cancer Database from 2004 to 2015 for cases of anal cancer stage groups 1 to 3, treated with definitive doses of radiation with chemotherapy. Dose escalation was defined as >54 Gy. Univariable and multivariable analyses were performed to identify factors predictive of dose, IMRT, and overall survival. Propensity-adjusted Cox proportional hazard ratios for survival were used to account for indication bias. Results: We identified 7792 patients meeting the eligibility criteria, with 4269 treated to doses of 45 to 54 Gy and 3163 treated to doses >54 Gy. Patients who were older, had government or private insurance, IMRT treatment, treatment at an academic center, or more recent years were less likely to get dose escalation. The use of dose escalation decreased over time, from 50% in 2005 to 30% in 2015. IMRT use increased over time from 2% to 63%. On multivariable analysis with propensity score included it was found that increased age, higher comorbidity score, lower income, shorter distance to facility, and male sex were predictive of decreased overall survival. In addition, escalated dose was associated with a lower survival (hazard ratio: 1.10, 95% confidence interval: 1.01-1.20, P =0.03). Conclusions: The results of this analysis show a steady increase in the use of IMRT, with corresponding decrease in dose escalation. These findings correlate with the results of RTOG 0529 establishing IMRT as standard of care for anal SCC, using doses of 50.4 to 54 Gy." @default.
• W2944307347 created "2019-05-16" @default.
• W2944307347 creator A5004037726 @default.
• W2944307347 creator A5021079245 @default.
• W2944307347 creator A5021211614 @default.
• W2944307347 creator A5025101096 @default.
• W2944307347 creator A5068614036 @default.
• W2944307347 creator A5070400110 @default.
• W2944307347 creator A5073682072 @default.
• W2944307347 creator A5078734526 @default.
• W2944307347 creator A5085389568 @default.
• W2944307347 date "2019-06-01" @default.
• W2944307347 modified "2023-10-18" @default.
• W2944307347 title "Trends in Radiation Dose and Technique For Anal Canal Squamous Cell Carcinoma" @default.
• W2944307347 cites W1979751190 @default.
• W2944307347 cites W1988506583 @default.
• W2944307347 cites W2004367809 @default.
• W2944307347 cites W2010602868 @default.
• W2944307347 cites W2067126590 @default.
• W2944307347 cites W2076341925 @default.
• W2944307347 cites W2083915572 @default.
• W2944307347 cites W2111714525 @default.
• W2944307347 cites W2121690051 @default.
• W2944307347 cites W2129168200 @default.
• W2944307347 cites W2158244375 @default.
• W2944307347 cites W2589045288 @default.
• W2944307347 cites W2745633799 @default.
• W2944307347 cites W2781525129 @default.
• W2944307347 cites W4211035194 @default.
• W2944307347 cites W4293241248 @default.
• W2944307347 cites W4367329884 @default.
• W2944307347 doi "https://doi.org/10.1097/coc.0000000000000551" @default.
• W2944307347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31136369" @default.
• W2944307347 hasPublicationYear "2019" @default.
• W2944307347 type Work @default.
• W2944307347 sameAs 2944307347 @default.
• W2944307347 citedByCount "0" @default.
• W2944307347 crossrefType "journal-article" @default.
• W2944307347 hasAuthorship W2944307347A5004037726 @default.
• W2944307347 hasAuthorship W2944307347A5021079245 @default.
• W2944307347 hasAuthorship W2944307347A5021211614 @default.
• W2944307347 hasAuthorship W2944307347A5025101096 @default.
• W2944307347 hasAuthorship W2944307347A5068614036 @default.
• W2944307347 hasAuthorship W2944307347A5070400110 @default.
• W2944307347 hasAuthorship W2944307347A5073682072 @default.
• W2944307347 hasAuthorship W2944307347A5078734526 @default.
• W2944307347 hasAuthorship W2944307347A5085389568 @default.
• W2944307347 hasConcept C121608353 @default.
• W2944307347 hasConcept C126322002 @default.
• W2944307347 hasConcept C126894567 @default.
• W2944307347 hasConcept C141071460 @default.
• W2944307347 hasConcept C143998085 @default.
• W2944307347 hasConcept C146357865 @default.
• W2944307347 hasConcept C151730666 @default.
• W2944307347 hasConcept C17923572 @default.
• W2944307347 hasConcept C207103383 @default.
• W2944307347 hasConcept C2779840525 @default.
• W2944307347 hasConcept C2989005 @default.
• W2944307347 hasConcept C44249647 @default.
• W2944307347 hasConcept C50382708 @default.
• W2944307347 hasConcept C509974204 @default.
• W2944307347 hasConcept C71924100 @default.
• W2944307347 hasConcept C86803240 @default.
• W2944307347 hasConceptScore W2944307347C121608353 @default.
• W2944307347 hasConceptScore W2944307347C126322002 @default.
• W2944307347 hasConceptScore W2944307347C126894567 @default.
• W2944307347 hasConceptScore W2944307347C141071460 @default.
• W2944307347 hasConceptScore W2944307347C143998085 @default.
• W2944307347 hasConceptScore W2944307347C146357865 @default.
• W2944307347 hasConceptScore W2944307347C151730666 @default.
• W2944307347 hasConceptScore W2944307347C17923572 @default.
• W2944307347 hasConceptScore W2944307347C207103383 @default.
• W2944307347 hasConceptScore W2944307347C2779840525 @default.
• W2944307347 hasConceptScore W2944307347C2989005 @default.
• W2944307347 hasConceptScore W2944307347C44249647 @default.
• W2944307347 hasConceptScore W2944307347C50382708 @default.
• W2944307347 hasConceptScore W2944307347C509974204 @default.
• W2944307347 hasConceptScore W2944307347C71924100 @default.
• W2944307347 hasConceptScore W2944307347C86803240 @default.
• W2944307347 hasIssue "6" @default.
• W2944307347 hasLocation W29443073471 @default.
• W2944307347 hasLocation W29443073472 @default.
• W2944307347 hasOpenAccess W2944307347 @default.
• W2944307347 hasPrimaryLocation W29443073471 @default.
• W2944307347 hasRelatedWork W1999460399 @default.
• W2944307347 hasRelatedWork W2605901636 @default.
• W2944307347 hasRelatedWork W2912909642 @default.
• W2944307347 hasRelatedWork W2937910201 @default.
• W2944307347 hasRelatedWork W2980864243 @default.
• W2944307347 hasRelatedWork W2997642176 @default.
• W2944307347 hasRelatedWork W3031953093 @default.
• W2944307347 hasRelatedWork W3143648732 @default.
• W2944307347 hasRelatedWork W4214554202 @default.
• W2944307347 hasRelatedWork W4244523620 @default.
• W2944307347 hasVolume "42" @default.
• W2944307347 isParatext "false" @default.
• W2944307347 isRetracted "false" @default.
• W2944307347 magId "2944307347" @default.

• next