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- W2944318063 abstract "Reelin is a large secreted protein that is essential for the development and function of the central nervous system. Dimerization and/or oligomerization is required for its biological activity, but the underlying mechanism is not fully understood. There are several widely used anti-Reelin antibodies and we noticed that their reactivity to monomeric or dimeric Reelin protein is different. We also found that their reactivity to Reelin in the solution or in fixed brain tissues also differs. Our results provide the information regarding how the N-terminal region of Reelin folds and contributes to the formation of higher order structure. We also provide a caveat that appropriate use of anti-Reelin antibody is necessary for quantitative analyses." @default.
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- W2944318063 date "2019-06-01" @default.
- W2944318063 modified "2023-10-16" @default.
- W2944318063 title "Differential binding of anti-Reelin monoclonal antibodies reveals the characteristics of Reelin protein under various conditions" @default.
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- W2944318063 doi "https://doi.org/10.1016/j.bbrc.2019.05.005" @default.
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