Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944318079> ?p ?o ?g. }
- W2944318079 endingPage "e0216142" @default.
- W2944318079 startingPage "e0216142" @default.
- W2944318079 abstract "Gastrotropin, the intracellular carrier of bile salts in the small intestine, binds two ligand molecules simultaneously in its internal cavity. The molecular rearrangements required for ligand entry are not yet fully clear. To improve our understanding of the binding process we combined molecular dynamics simulations with previously published structural and dynamic NMR parameters. The resulting ensembles reveal two distinct modes of barrel opening with one corresponding to the transition between the apo and holo states, whereas the other affecting different protein regions in both ligation states. Comparison of the calculated structures with NMR-derived parameters reporting on slow conformational exchange processes suggests that the protein undergoes partial unfolding along a path related to the second mode of the identified barrel opening motion." @default.
- W2944318079 created "2019-05-16" @default.
- W2944318079 creator A5044402680 @default.
- W2944318079 creator A5071671589 @default.
- W2944318079 creator A5084271502 @default.
- W2944318079 creator A5091123400 @default.
- W2944318079 date "2019-05-10" @default.
- W2944318079 modified "2023-10-17" @default.
- W2944318079 title "Different modes of barrel opening suggest a complex pathway of ligand binding in human gastrotropin" @default.
- W2944318079 cites W1484090198 @default.
- W2944318079 cites W1516972356 @default.
- W2944318079 cites W1966951295 @default.
- W2944318079 cites W1969694799 @default.
- W2944318079 cites W1971251199 @default.
- W2944318079 cites W1972168184 @default.
- W2944318079 cites W1974831269 @default.
- W2944318079 cites W1975852583 @default.
- W2944318079 cites W1976499671 @default.
- W2944318079 cites W1981438488 @default.
- W2944318079 cites W1991176640 @default.
- W2944318079 cites W1995249263 @default.
- W2944318079 cites W1997016617 @default.
- W2944318079 cites W2002121467 @default.
- W2944318079 cites W2008282292 @default.
- W2944318079 cites W2020535309 @default.
- W2944318079 cites W2029120587 @default.
- W2944318079 cites W2029667189 @default.
- W2944318079 cites W2043374563 @default.
- W2944318079 cites W2054730323 @default.
- W2944318079 cites W2055678922 @default.
- W2944318079 cites W2069421207 @default.
- W2944318079 cites W2071450296 @default.
- W2944318079 cites W2071800700 @default.
- W2944318079 cites W2072090658 @default.
- W2944318079 cites W2076223436 @default.
- W2944318079 cites W2076381384 @default.
- W2944318079 cites W2080774916 @default.
- W2944318079 cites W2095584875 @default.
- W2944318079 cites W2095805596 @default.
- W2944318079 cites W2102377211 @default.
- W2944318079 cites W2103637349 @default.
- W2944318079 cites W2118258049 @default.
- W2944318079 cites W2123681603 @default.
- W2944318079 cites W2123912428 @default.
- W2944318079 cites W2128572087 @default.
- W2944318079 cites W2131529311 @default.
- W2944318079 cites W2132629607 @default.
- W2944318079 cites W2158053813 @default.
- W2944318079 cites W2160544821 @default.
- W2944318079 cites W2171268876 @default.
- W2944318079 cites W2288524873 @default.
- W2944318079 cites W2324395498 @default.
- W2944318079 cites W250963869 @default.
- W2944318079 cites W2595163574 @default.
- W2944318079 cites W2607560340 @default.
- W2944318079 cites W2735337565 @default.
- W2944318079 cites W2752926875 @default.
- W2944318079 cites W2915248527 @default.
- W2944318079 doi "https://doi.org/10.1371/journal.pone.0216142" @default.
- W2944318079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6510414" @default.
- W2944318079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31075121" @default.
- W2944318079 hasPublicationYear "2019" @default.
- W2944318079 type Work @default.
- W2944318079 sameAs 2944318079 @default.
- W2944318079 citedByCount "2" @default.
- W2944318079 countsByYear W29443180792022 @default.
- W2944318079 crossrefType "journal-article" @default.
- W2944318079 hasAuthorship W2944318079A5044402680 @default.
- W2944318079 hasAuthorship W2944318079A5071671589 @default.
- W2944318079 hasAuthorship W2944318079A5084271502 @default.
- W2944318079 hasAuthorship W2944318079A5091123400 @default.
- W2944318079 hasBestOaLocation W29443180791 @default.
- W2944318079 hasConcept C116569031 @default.
- W2944318079 hasConcept C12554922 @default.
- W2944318079 hasConcept C147597530 @default.
- W2944318079 hasConcept C159985019 @default.
- W2944318079 hasConcept C170493617 @default.
- W2944318079 hasConcept C172227984 @default.
- W2944318079 hasConcept C178790620 @default.
- W2944318079 hasConcept C185592680 @default.
- W2944318079 hasConcept C192562407 @default.
- W2944318079 hasConcept C32909587 @default.
- W2944318079 hasConcept C47701112 @default.
- W2944318079 hasConcept C51639874 @default.
- W2944318079 hasConcept C55493867 @default.
- W2944318079 hasConcept C59593255 @default.
- W2944318079 hasConcept C8010536 @default.
- W2944318079 hasConcept C86803240 @default.
- W2944318079 hasConceptScore W2944318079C116569031 @default.
- W2944318079 hasConceptScore W2944318079C12554922 @default.
- W2944318079 hasConceptScore W2944318079C147597530 @default.
- W2944318079 hasConceptScore W2944318079C159985019 @default.
- W2944318079 hasConceptScore W2944318079C170493617 @default.
- W2944318079 hasConceptScore W2944318079C172227984 @default.
- W2944318079 hasConceptScore W2944318079C178790620 @default.
- W2944318079 hasConceptScore W2944318079C185592680 @default.
- W2944318079 hasConceptScore W2944318079C192562407 @default.
- W2944318079 hasConceptScore W2944318079C32909587 @default.