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- W2944331363 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Praziquantel, as the only drug for the treatment of schistosomiasis, is under serious threat due to the emergence of resistant strains of <ns4:italic>Schistosoma</ns4:italic> species. There is an urgent need to search for alternative chemotherapy to supplement or complement praziquantel. <ns4:italic>Schistosoma</ns4:italic> dihydroorotate dehydrogenase (DHODH) has been recommended as a druggable target for schistosomiasis chemotherapy. The development of novel molecular modeling approaches, alongside with computational tools and rapid sequencing of pathogen genomes, have facilitated drug discovery. Therefore, the aim of this study was to employ computational approaches to screen compounds against <ns4:italic>Schistosoma mansoni</ns4:italic> DHODH.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> In this study, DHODH was used to blast on the latest version of DrugBank that contained 12,110 compounds, resulting in 26 drugs that can bind.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> <ns4:italic>In silico</ns4:italic> docking shows that 13 drugs can bind strongly with an estimated free energy of binding, total intermolecular energy and estimated inhibition constant (Ki) greater than or equal to -8.6 kcal/mol, -8.12 kcal/mol and 1.12 µM, respectively. These compounds include the approved drugs manitimus, capecitabine, brequinar analog and leflunomide.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> These results indicate that these drugs have the potential for use in the control of schistosomiasis in the future.</ns4:p>" @default.
- W2944331363 created "2019-05-16" @default.
- W2944331363 creator A5058182664 @default.
- W2944331363 date "2019-05-13" @default.
- W2944331363 modified "2023-10-14" @default.
- W2944331363 title "Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs" @default.
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