FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944332595> ?p ?o ?g. }

• W2944332595 endingPage "6" @default.
• W2944332595 startingPage "1" @default.
• W2944332595 abstract "At present, extensive hysterectomy and pelvic lymph node dissection are preferred for early-stage cervical cancer. However, additional adjuvant therapy could be considered if there is a risk for recurrence. Postoperative pelvic radiotherapy plus concurrent platinum-based chemotherapy are recommended for patients with high risk factors. The treatment regimen for patients with intermediate-risk factors, however, remains unclear. We, thus, performed a systematic review and meta-analysis to assess the recurrence-free survival (RFS), overall survival (OS), grade III/IV hematologic toxicity and grade III/IV non-hematologic toxicity in chemoradiotherapy (CRT) versus radiotherapy (RT) groups.We systematically searched PubMed, Cochrane, and Embase to identify relevant studies published before November 30, 2018 to compare CRT with RT as a postoperative adjuvant therapy in early-stage cervical cancer patients with intermediate-risk factors. We used Stata (version 14.0) to calculate odds risks (ORs) and 95% confidence intervals (CIs) and pooled data was assessed by the fixed-effects model.Of the 428 identified studies, only 9 were eligible and included in our analysis (CRT: n = 870; RT: n = 932). CRT significantly prolonged RFS (OR = 3.43, 95% CI 2.08-5.67, P = 0.000) and OS (OR = 1.80, 95% CI 1.30-2.50, P = 0.000). The occurrence rate of grade III/IV hematologic toxicity (OR = 16.07, 95% CI 6.47-39.93, P = 0.000) was significantly higher in CRT, while grade III/IV non-hematologic toxicity was ambiguous for CRT and RT with an OR of 1.91 (95% CI 0.95-3.83, P = 0.069).For early-stage cervical cancer patients with intermediate-risk factors, CRT can dramatically improve RFS and OS compared with RT. Apart from the increase in grade III/IV hematologic toxicity, CRT was well tolerated and accepted treatment for early-stage cervical cancer." @default.
• W2944332595 created "2019-05-16" @default.
• W2944332595 creator A5051444274 @default.
• W2944332595 creator A5054729890 @default.
• W2944332595 creator A5057500547 @default.
• W2944332595 creator A5087592842 @default.
• W2944332595 date "2019-07-01" @default.
• W2944332595 modified "2023-10-01" @default.
• W2944332595 title "Adjuvant chemoradiotherapy versus radiotherapy in cervical cancer patients with intermediate-risk factors: A systematic review and meta-analysis" @default.
• W2944332595 cites W1935824237 @default.
• W2944332595 cites W1990069551 @default.
• W2944332595 cites W1991286856 @default.
• W2944332595 cites W1992950046 @default.
• W2944332595 cites W1994253681 @default.
• W2944332595 cites W1995170578 @default.
• W2944332595 cites W2000715336 @default.
• W2944332595 cites W2013567354 @default.
• W2944332595 cites W2015518534 @default.
• W2944332595 cites W2033585778 @default.
• W2944332595 cites W2053512733 @default.
• W2944332595 cites W2070789376 @default.
• W2944332595 cites W2077200534 @default.
• W2944332595 cites W2123297927 @default.
• W2944332595 cites W2125435699 @default.
• W2944332595 cites W2126930838 @default.
• W2944332595 cites W2134833483 @default.
• W2944332595 cites W2137347767 @default.
• W2944332595 cites W2157719711 @default.
• W2944332595 cites W2261525788 @default.
• W2944332595 cites W2314753133 @default.
• W2944332595 cites W2519324524 @default.
• W2944332595 cites W2538112600 @default.
• W2944332595 cites W2558331009 @default.
• W2944332595 cites W2737137651 @default.
• W2944332595 cites W2794380616 @default.
• W2944332595 cites W2909503380 @default.
• W2944332595 cites W2919025598 @default.
• W2944332595 doi "https://doi.org/10.1016/j.ejogrb.2019.04.039" @default.
• W2944332595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31082737" @default.
• W2944332595 hasPublicationYear "2019" @default.
• W2944332595 type Work @default.
• W2944332595 sameAs 2944332595 @default.
• W2944332595 citedByCount "14" @default.
• W2944332595 countsByYear W29443325952020 @default.
• W2944332595 countsByYear W29443325952021 @default.
• W2944332595 countsByYear W29443325952022 @default.
• W2944332595 countsByYear W29443325952023 @default.
• W2944332595 crossrefType "journal-article" @default.
• W2944332595 hasAuthorship W2944332595A5051444274 @default.
• W2944332595 hasAuthorship W2944332595A5054729890 @default.
• W2944332595 hasAuthorship W2944332595A5057500547 @default.
• W2944332595 hasAuthorship W2944332595A5087592842 @default.
• W2944332595 hasConcept C121608353 @default.
• W2944332595 hasConcept C126322002 @default.
• W2944332595 hasConcept C141071460 @default.
• W2944332595 hasConcept C143998085 @default.
• W2944332595 hasConcept C156957248 @default.
• W2944332595 hasConcept C2778220009 @default.
• W2944332595 hasConcept C2778424827 @default.
• W2944332595 hasConcept C2781413609 @default.
• W2944332595 hasConcept C44249647 @default.
• W2944332595 hasConcept C509974204 @default.
• W2944332595 hasConcept C71924100 @default.
• W2944332595 hasConcept C95190672 @default.
• W2944332595 hasConceptScore W2944332595C121608353 @default.
• W2944332595 hasConceptScore W2944332595C126322002 @default.
• W2944332595 hasConceptScore W2944332595C141071460 @default.
• W2944332595 hasConceptScore W2944332595C143998085 @default.
• W2944332595 hasConceptScore W2944332595C156957248 @default.
• W2944332595 hasConceptScore W2944332595C2778220009 @default.
• W2944332595 hasConceptScore W2944332595C2778424827 @default.
• W2944332595 hasConceptScore W2944332595C2781413609 @default.
• W2944332595 hasConceptScore W2944332595C44249647 @default.
• W2944332595 hasConceptScore W2944332595C509974204 @default.
• W2944332595 hasConceptScore W2944332595C71924100 @default.
• W2944332595 hasConceptScore W2944332595C95190672 @default.
• W2944332595 hasLocation W29443325951 @default.
• W2944332595 hasLocation W29443325952 @default.
• W2944332595 hasOpenAccess W2944332595 @default.
• W2944332595 hasPrimaryLocation W29443325951 @default.
• W2944332595 hasRelatedWork W1976427052 @default.
• W2944332595 hasRelatedWork W2032438949 @default.
• W2944332595 hasRelatedWork W2047252483 @default.
• W2944332595 hasRelatedWork W2286371484 @default.
• W2944332595 hasRelatedWork W2318119155 @default.
• W2944332595 hasRelatedWork W2384708512 @default.
• W2944332595 hasRelatedWork W2389902761 @default.
• W2944332595 hasRelatedWork W2747332931 @default.
• W2944332595 hasRelatedWork W4245694863 @default.
• W2944332595 hasRelatedWork W4253632170 @default.
• W2944332595 hasVolume "238" @default.
• W2944332595 isParatext "false" @default.
• W2944332595 isRetracted "false" @default.
• W2944332595 magId "2944332595" @default.
• W2944332595 workType "article" @default.