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- W2944337310 endingPage "14212" @default.
- W2944337310 startingPage "14201" @default.
- W2944337310 abstract "Eukaryotic initiation factor 4E (eIF4E), a fundamental effector and rate limiting element of protein synthesis, binds the 7-methylguanosine cap at the 5' end of eukaryotic messenger RNA (mRNA) specifically as a constituent of eIF4F translation initiation complex thus facilitating the recruitment of mRNA to the ribosomes. This review focusses on the engagement of signals contributing to growth factor originated maxim and their role in the activation of eIF4E to achieve a collective influence on cellular growth, with a key focus on conjuring vital processes like protein synthesis. The review invites considerable interest in elevating the appeal of eIF4E beyond its role in regulating translation viz a viz cancer genesis, attributed to its phosphorylation state that improves the prospect for the growth of the cancerous cell. This review highlights the latest studies that have envisioned to target these pathways and ultimately the translational machinery for therapeutic intervention. The review also brings forward the prospect of eIF4E to act as a converging juncture for signaling pathways like mTOR/PI3K and Mnk/MAPK to promote tumorigenesis." @default.
- W2944337310 created "2019-05-16" @default.
- W2944337310 creator A5016717497 @default.
- W2944337310 creator A5025043201 @default.
- W2944337310 creator A5046479511 @default.
- W2944337310 date "2019-05-09" @default.
- W2944337310 modified "2023-10-12" @default.
- W2944337310 title "Eukaryotic initiation factor 4E (eIF4E): A recap of the cap‐binding protein" @default.
- W2944337310 cites W106738307 @default.
- W2944337310 cites W1526832384 @default.
- W2944337310 cites W1592379748 @default.
- W2944337310 cites W1594354817 @default.
- W2944337310 cites W1608233475 @default.
- W2944337310 cites W1626240090 @default.
- W2944337310 cites W1901840084 @default.
- W2944337310 cites W1902360513 @default.
- W2944337310 cites W1966059275 @default.
- W2944337310 cites W1968260551 @default.
- W2944337310 cites W1968700203 @default.
- W2944337310 cites W1968919723 @default.
- W2944337310 cites W1969497469 @default.
- W2944337310 cites W1976198410 @default.
- W2944337310 cites W1986308117 @default.
- W2944337310 cites W1986781282 @default.
- W2944337310 cites W1987452803 @default.
- W2944337310 cites W1988640094 @default.
- W2944337310 cites W1992226313 @default.
- W2944337310 cites W1992631886 @default.
- W2944337310 cites W1993287040 @default.
- W2944337310 cites W1997806157 @default.
- W2944337310 cites W2001443196 @default.
- W2944337310 cites W2001953649 @default.
- W2944337310 cites W2005056727 @default.
- W2944337310 cites W2006574484 @default.
- W2944337310 cites W2013499550 @default.
- W2944337310 cites W2014226478 @default.
- W2944337310 cites W2018500072 @default.
- W2944337310 cites W2030801461 @default.
- W2944337310 cites W2031216046 @default.
- W2944337310 cites W2032319312 @default.
- W2944337310 cites W2032666422 @default.
- W2944337310 cites W2033171415 @default.
- W2944337310 cites W2037532701 @default.
- W2944337310 cites W2038146634 @default.
- W2944337310 cites W2038423179 @default.
- W2944337310 cites W2045360857 @default.
- W2944337310 cites W2046822015 @default.
- W2944337310 cites W2047104027 @default.
- W2944337310 cites W2048862315 @default.
- W2944337310 cites W2049053321 @default.
- W2944337310 cites W2051430639 @default.
- W2944337310 cites W2052001124 @default.
- W2944337310 cites W2053304186 @default.
- W2944337310 cites W2056755041 @default.
- W2944337310 cites W2057760613 @default.
- W2944337310 cites W2057906496 @default.
- W2944337310 cites W2062832479 @default.
- W2944337310 cites W2065591579 @default.
- W2944337310 cites W2065613854 @default.
- W2944337310 cites W2066394912 @default.
- W2944337310 cites W2069824527 @default.
- W2944337310 cites W2070329174 @default.
- W2944337310 cites W2075420263 @default.
- W2944337310 cites W2075511135 @default.
- W2944337310 cites W2079351077 @default.
- W2944337310 cites W2079645717 @default.
- W2944337310 cites W2082834726 @default.
- W2944337310 cites W2086938346 @default.
- W2944337310 cites W2088256943 @default.
- W2944337310 cites W2088819616 @default.
- W2944337310 cites W2089020035 @default.
- W2944337310 cites W2089265649 @default.
- W2944337310 cites W2093408431 @default.
- W2944337310 cites W2100468603 @default.
- W2944337310 cites W2102148658 @default.
- W2944337310 cites W2102889876 @default.
- W2944337310 cites W2103588034 @default.
- W2944337310 cites W2107495112 @default.
- W2944337310 cites W2112519486 @default.
- W2944337310 cites W2112618792 @default.
- W2944337310 cites W2116761906 @default.
- W2944337310 cites W2121647526 @default.
- W2944337310 cites W2127227052 @default.
- W2944337310 cites W2127329372 @default.
- W2944337310 cites W2129069292 @default.
- W2944337310 cites W2129615992 @default.
- W2944337310 cites W2132519593 @default.
- W2944337310 cites W2134052952 @default.
- W2944337310 cites W2136159122 @default.
- W2944337310 cites W2136272779 @default.
- W2944337310 cites W2147997023 @default.
- W2944337310 cites W2148892576 @default.
- W2944337310 cites W2148915086 @default.
- W2944337310 cites W2163107196 @default.
- W2944337310 cites W2169821980 @default.
- W2944337310 cites W2170137742 @default.
- W2944337310 cites W2236156346 @default.
- W2944337310 cites W2290900334 @default.