FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944418423> ?p ?o ?g. }

• W2944418423 endingPage "042090" @default.
• W2944418423 startingPage "042090" @default.
• W2944418423 abstract "Clematis chinensis is a traditional Chinese medicine with good anti-inflammatory effects, but the underlying molecular mechanism is unclear. In this work, the potential mechanism of Clematis chinensis with anti-inflammatory effect was explored using the network pharmacology. The active chemical constituents of Clematis chinensis were screened according to the pharmacodynamic activities and ADME parameters, then the potential anti-inflammatory targets of the active chemical constituents in Clematis chinensis were screened with the databases of TCMSP, PubChem, TCMID, etc., and the target data sets were established through the BATMAN-TCM database, traditional Chinese medicine target database, HIT database, and TTD database. The targets related to inflammation were screened by using OMIM database, and the interactive target between clematis chinensis and inflammation were constructed by using PPI database. The complex network map of drug composition-target-disease was constructed by Cytoscape software, and GO (gene function) analysis was carried out by using ClueGO plug-in. Protein interaction analysis, target gene function enrichment analysis, and signal pathway analysis were carried out by STRING database, biological information annotation database (DAVID), and KEGG Pathway database. 39 out of 458 chemical constituents of Clematis chinensis had good drug-likeness and activity. 35 key targets were screened out by Degree, Betweenness Centrality, Closeness Centrality, and other network topology characteristics, and these targets were involved in 25 signaling pathways related to the anti-inflammatory action including TNF signaling pathway, MAPK signaling pathway, NF-kappa B signaling pathway, etc. In addition, it was also related to the positive and negative regulation of many biological processes such as inflammatory response, positive regulation of I-kappaB, kinase/NF-kappaB signaling, positive regulation of NF-kappaB, etc. The TNF signaling pathway, MAPK signaling pathway, and NF-kappa B signaling pathway were closely related to the anti-inflammatory activity of Clematis chinensis. Network pharmacology could be used to study the anti-inflammatory molecular mechanism of Clematis chinensis, which is beneficial to the development and utilization of Clematis chinensis." @default.
• W2944418423 created "2019-05-16" @default.
• W2944418423 creator A5018896568 @default.
• W2944418423 creator A5024050425 @default.
• W2944418423 creator A5034938775 @default.
• W2944418423 creator A5037406204 @default.
• W2944418423 creator A5055088908 @default.
• W2944418423 creator A5069379221 @default.
• W2944418423 creator A5080896986 @default.
• W2944418423 creator A5089366650 @default.
• W2944418423 date "2019-04-01" @default.
• W2944418423 modified "2023-09-27" @default.
• W2944418423 title "Prediction of the Anti-inflammatory Mechanism of Clematis chinensis based on Network Pharmacology" @default.
• W2944418423 cites W2039773044 @default.
• W2944418423 cites W2045528558 @default.
• W2944418423 cites W2116036853 @default.
• W2944418423 cites W2135385212 @default.
• W2944418423 cites W2324373748 @default.
• W2944418423 doi "https://doi.org/10.1088/1742-6596/1187/4/042090" @default.
• W2944418423 hasPublicationYear "2019" @default.
• W2944418423 type Work @default.
• W2944418423 sameAs 2944418423 @default.
• W2944418423 citedByCount "0" @default.
• W2944418423 crossrefType "journal-article" @default.
• W2944418423 hasAuthorship W2944418423A5018896568 @default.
• W2944418423 hasAuthorship W2944418423A5024050425 @default.
• W2944418423 hasAuthorship W2944418423A5034938775 @default.
• W2944418423 hasAuthorship W2944418423A5037406204 @default.
• W2944418423 hasAuthorship W2944418423A5055088908 @default.
• W2944418423 hasAuthorship W2944418423A5069379221 @default.
• W2944418423 hasAuthorship W2944418423A5080896986 @default.
• W2944418423 hasAuthorship W2944418423A5089366650 @default.
• W2944418423 hasBestOaLocation W29444184231 @default.
• W2944418423 hasConcept C104317684 @default.
• W2944418423 hasConcept C111472728 @default.
• W2944418423 hasConcept C138885662 @default.
• W2944418423 hasConcept C142724271 @default.
• W2944418423 hasConcept C150194340 @default.
• W2944418423 hasConcept C152724338 @default.
• W2944418423 hasConcept C155261790 @default.
• W2944418423 hasConcept C158180186 @default.
• W2944418423 hasConcept C162317418 @default.
• W2944418423 hasConcept C188947578 @default.
• W2944418423 hasConcept C204787440 @default.
• W2944418423 hasConcept C2779824472 @default.
• W2944418423 hasConcept C2780035454 @default.
• W2944418423 hasConcept C2780344312 @default.
• W2944418423 hasConcept C2991655182 @default.
• W2944418423 hasConcept C54355233 @default.
• W2944418423 hasConcept C556039675 @default.
• W2944418423 hasConcept C70721500 @default.
• W2944418423 hasConcept C71924100 @default.
• W2944418423 hasConcept C86803240 @default.
• W2944418423 hasConcept C89611455 @default.
• W2944418423 hasConcept C98274493 @default.
• W2944418423 hasConceptScore W2944418423C104317684 @default.
• W2944418423 hasConceptScore W2944418423C111472728 @default.
• W2944418423 hasConceptScore W2944418423C138885662 @default.
• W2944418423 hasConceptScore W2944418423C142724271 @default.
• W2944418423 hasConceptScore W2944418423C150194340 @default.
• W2944418423 hasConceptScore W2944418423C152724338 @default.
• W2944418423 hasConceptScore W2944418423C155261790 @default.
• W2944418423 hasConceptScore W2944418423C158180186 @default.
• W2944418423 hasConceptScore W2944418423C162317418 @default.
• W2944418423 hasConceptScore W2944418423C188947578 @default.
• W2944418423 hasConceptScore W2944418423C204787440 @default.
• W2944418423 hasConceptScore W2944418423C2779824472 @default.
• W2944418423 hasConceptScore W2944418423C2780035454 @default.
• W2944418423 hasConceptScore W2944418423C2780344312 @default.
• W2944418423 hasConceptScore W2944418423C2991655182 @default.
• W2944418423 hasConceptScore W2944418423C54355233 @default.
• W2944418423 hasConceptScore W2944418423C556039675 @default.
• W2944418423 hasConceptScore W2944418423C70721500 @default.
• W2944418423 hasConceptScore W2944418423C71924100 @default.
• W2944418423 hasConceptScore W2944418423C86803240 @default.
• W2944418423 hasConceptScore W2944418423C89611455 @default.
• W2944418423 hasConceptScore W2944418423C98274493 @default.
• W2944418423 hasIssue "4" @default.
• W2944418423 hasLocation W29444184231 @default.
• W2944418423 hasOpenAccess W2944418423 @default.
• W2944418423 hasPrimaryLocation W29444184231 @default.
• W2944418423 hasRelatedWork W113990377 @default.
• W2944418423 hasRelatedWork W1993352447 @default.
• W2944418423 hasRelatedWork W2017360600 @default.
• W2944418423 hasRelatedWork W2967071056 @default.
• W2944418423 hasRelatedWork W3154968664 @default.
• W2944418423 hasRelatedWork W3164508606 @default.
• W2944418423 hasRelatedWork W4212847702 @default.
• W2944418423 hasRelatedWork W4213280854 @default.
• W2944418423 hasRelatedWork W4285026760 @default.
• W2944418423 hasRelatedWork W4288717655 @default.
• W2944418423 hasVolume "1187" @default.
• W2944418423 isParatext "false" @default.
• W2944418423 isRetracted "false" @default.
• W2944418423 magId "2944418423" @default.
• W2944418423 workType "article" @default.