FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944420215> ?p ?o ?g. }

• W2944420215 endingPage "135013" @default.
• W2944420215 startingPage "135013" @default.
• W2944420215 abstract "Abstract Small animal x-ray irradiation platforms are expanding the capabilities and future pathways for radiobiology research. Meanwhile, proton radiotherapy is transitioning to a standard treatment modality in the clinician’s precision radiotherapy toolbox, highlighting a gap between state-of-the-art clinical radiotherapy and small animal radiobiology research. Comparative research of the biological differences between proton and x-ray beams could benefit from an integrated small animal irradiation system for in vivo experiments and corresponding quality assurance (QA) protocols to ensure rigor and reproducibility. The objective of this study is to incorporate a proton beam into a small animal radiotherapy platform while implementing QA modelled after clinical protocols. A 225 kV x-ray small animal radiation research platform (SARRP) was installed on rails to align with a modified proton experimental beamline from a 230 MeV cyclotron-based clinical system. Collimated spread out Bragg peaks (SOBP) were produced with beam parameters compatible with small animal irradiation. Proton beam characteristics were measured and alignment reproducibility with the x-ray system isocenter was evaluated. A QA protocol was designed to ensure consistent proton beam quality and alignment. As a preliminary study, cellular damage via γ -H2AX immunofluorescence staining in an irradiated mouse tumor model was used to verify the beam range in vivo . The beam line was commissioned to deliver Bragg peaks with range 4–30 mm in water at 2 Gy min −1 . SOBPs were delivered with width up to 25 mm. Proton beam alignment with the x-ray system agreed within 0.5 mm. A QA phantom was created to ensure reproducible alignment of the platform and verify beam delivery. γ -H2AX staining verified expected proton range in vivo . An image-guided small animal proton/x-ray research system was developed to enable in vivo investigations of radiobiological effects of proton beams, comparative studies between proton and x-ray beams, and investigations into novel proton treatment methods." @default.
• W2944420215 created "2019-05-16" @default.
• W2944420215 creator A5030864083 @default.
• W2944420215 creator A5043954299 @default.
• W2944420215 creator A5051724496 @default.
• W2944420215 creator A5070392597 @default.
• W2944420215 creator A5071888692 @default.
• W2944420215 creator A5072987059 @default.
• W2944420215 creator A5080815829 @default.
• W2944420215 creator A5082801249 @default.
• W2944420215 creator A5088502637 @default.
• W2944420215 date "2019-07-01" @default.
• W2944420215 modified "2023-09-30" @default.
• W2944420215 title "Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research" @default.
• W2944420215 cites W1002368980 @default.
• W2944420215 cites W1530233947 @default.
• W2944420215 cites W1735419740 @default.
• W2944420215 cites W1994952741 @default.
• W2944420215 cites W2017613801 @default.
• W2944420215 cites W2025281204 @default.
• W2944420215 cites W2036417164 @default.
• W2944420215 cites W2056525990 @default.
• W2944420215 cites W2068151001 @default.
• W2944420215 cites W2081384891 @default.
• W2944420215 cites W2137020482 @default.
• W2944420215 cites W2140370697 @default.
• W2944420215 cites W2166220537 @default.
• W2944420215 cites W2170619710 @default.
• W2944420215 cites W2194922715 @default.
• W2944420215 cites W2404866675 @default.
• W2944420215 cites W2469530965 @default.
• W2944420215 cites W2561956400 @default.
• W2944420215 cites W2567513983 @default.
• W2944420215 cites W2738726226 @default.
• W2944420215 cites W2753759476 @default.
• W2944420215 cites W2765455963 @default.
• W2944420215 cites W2781466656 @default.
• W2944420215 cites W2791256345 @default.
• W2944420215 cites W2795949031 @default.
• W2944420215 doi "https://doi.org/10.1088/1361-6560/ab20d9" @default.
• W2944420215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31075786" @default.
• W2944420215 hasPublicationYear "2019" @default.
• W2944420215 type Work @default.
• W2944420215 sameAs 2944420215 @default.
• W2944420215 citedByCount "19" @default.
• W2944420215 countsByYear W29444202152020 @default.
• W2944420215 countsByYear W29444202152021 @default.
• W2944420215 countsByYear W29444202152022 @default.
• W2944420215 countsByYear W29444202152023 @default.
• W2944420215 crossrefType "journal-article" @default.
• W2944420215 hasAuthorship W2944420215A5030864083 @default.
• W2944420215 hasAuthorship W2944420215A5043954299 @default.
• W2944420215 hasAuthorship W2944420215A5051724496 @default.
• W2944420215 hasAuthorship W2944420215A5070392597 @default.
• W2944420215 hasAuthorship W2944420215A5071888692 @default.
• W2944420215 hasAuthorship W2944420215A5072987059 @default.
• W2944420215 hasAuthorship W2944420215A5080815829 @default.
• W2944420215 hasAuthorship W2944420215A5082801249 @default.
• W2944420215 hasAuthorship W2944420215A5088502637 @default.
• W2944420215 hasBestOaLocation W29444202151 @default.
• W2944420215 hasConcept C104293457 @default.
• W2944420215 hasConcept C106436119 @default.
• W2944420215 hasConcept C111337013 @default.
• W2944420215 hasConcept C120665830 @default.
• W2944420215 hasConcept C121332964 @default.
• W2944420215 hasConcept C125118446 @default.
• W2944420215 hasConcept C126838900 @default.
• W2944420215 hasConcept C136959337 @default.
• W2944420215 hasConcept C142724271 @default.
• W2944420215 hasConcept C168834538 @default.
• W2944420215 hasConcept C181401712 @default.
• W2944420215 hasConcept C185544564 @default.
• W2944420215 hasConcept C185592680 @default.
• W2944420215 hasConcept C19527891 @default.
• W2944420215 hasConcept C2778618615 @default.
• W2944420215 hasConcept C2779244869 @default.
• W2944420215 hasConcept C2780944729 @default.
• W2944420215 hasConcept C2781298738 @default.
• W2944420215 hasConcept C2989005 @default.
• W2944420215 hasConcept C34445779 @default.
• W2944420215 hasConcept C43617362 @default.
• W2944420215 hasConcept C509974204 @default.
• W2944420215 hasConcept C520434653 @default.
• W2944420215 hasConcept C54516573 @default.
• W2944420215 hasConcept C71924100 @default.
• W2944420215 hasConcept C9893847 @default.
• W2944420215 hasConceptScore W2944420215C104293457 @default.
• W2944420215 hasConceptScore W2944420215C106436119 @default.
• W2944420215 hasConceptScore W2944420215C111337013 @default.
• W2944420215 hasConceptScore W2944420215C120665830 @default.
• W2944420215 hasConceptScore W2944420215C121332964 @default.
• W2944420215 hasConceptScore W2944420215C125118446 @default.
• W2944420215 hasConceptScore W2944420215C126838900 @default.
• W2944420215 hasConceptScore W2944420215C136959337 @default.
• W2944420215 hasConceptScore W2944420215C142724271 @default.
• W2944420215 hasConceptScore W2944420215C168834538 @default.
• W2944420215 hasConceptScore W2944420215C181401712 @default.
• W2944420215 hasConceptScore W2944420215C185544564 @default.

• next