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• W2944458595 abstract "Rationale γ‐Hydroxybutyric acid (GHB) is a naturally endogenous neurotransmitter that is popular as a recreational drug due to its sedative, hypnotic, and euphoric effects. GHB derived from endogenous production or exogenous ingestion has been effectively discriminated by carbon isotopic compositions (δ 13 C values) through gas chromatography/combustion‐isotope ratio mass spectrometry (GC/C‐IRMS). However, an unintended uncertainty of isotopic signatures caused by a wide range of GHB quantities remains unsolved when using only single‐isotope corrections of the di‐TMS derivative. Methods The δ 13 C values of the original GHB standard were first determined by elemental analyzer/isotope ratio mass spectrometry (EA/IRMS). The δ 13 C values of silylated GHB in concentrations from 10 to 500 ppm were determined by GC/C‐IRMS. With respect to the silylated reaction products, the correction of δ 13 C values for the introduced carbons was calculated from a stoichiometric mass balance equation. Results The results showed a significant quantity‐dependent trend in δ 13 C values of introduced carbon (δ 13 C di‐TMS values) with increased GHB standard concentrations (r 2 = 0.70, p <0.05). We applied a logarithmic equation to determine isotopic data in low‐GHB urine specimens from five healthy female volunteers. The δ 13 C GHB values in urine samples corrected with quantity‐dependent δ 13 C di‐TMS values were different by an average of 2.7‰ from those corrected with single δ 13 C di‐TMS values ( p <0.05). Conclusions Our results suggest that the overall residual amount‐dependent isotope fractionation should be mathematically corrected by the logarithmic function and this may improve the reliability of isotopic analysis to evaluate the origin of GHB before applying the approach to routine toxicological and forensic studies." @default.
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• W2944458595 date "2019-08-06" @default.
• W2944458595 modified "2023-09-28" @default.
• W2944458595 title "Complementary approach for accurate determination of carbon isotopic compositions in γ‐hydroxybutyric acid using gas chromatography/combustion‐isotope ratio mass spectrometry" @default.
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• W2944458595 doi "https://doi.org/10.1002/rcm.8481" @default.
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