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- W2944486569 abstract "Cardiogenic shock (CS) is a complex and highly morbid entity conceptualised as a vicious cycle of injury, cardiac and systemic decompensation, and further injury and decompensation. The pathophysiology of CS is incompletely understood but limited clinical trial experience suggests that early and robust support of the failing heart to allow for restoration of systemic homoeostasis appears critical for survival. We review the pathophysiology, clinical features and trial data to construct a contemporary model of CS as a systemic process characterised with maladaptive compensatory mechanisms requiring prompt and appropriately tailored medical and mechanical support for optimal outcomes. We conclude with an algorithmic approach to acute CS incorporating clinical and haemodynamic data to match the patient’s cardiac and systemic needs as a template for contemporary management." @default.
- W2944486569 created "2019-05-16" @default.
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- W2944486569 date "2019-05-01" @default.
- W2944486569 modified "2023-10-10" @default.
- W2944486569 title "Cardiogenic shock: evolving definitions and future directions in management" @default.
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- W2944486569 doi "https://doi.org/10.1136/openhrt-2018-000960" @default.
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