FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944537177> ?p ?o ?g. }

• W2944537177 abstract "Background: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude. CIH is associated with repetitive acute hypoxic acclimatization and conveys the long-term risk of HAPH. As nitric oxide (NO) regulates pulmonary vascular tone and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthesis, we investigated whether ADMA concentration at sea level predicts HAPH among Chilean frontiers personnel exposed to 6 months of CIH. Methods: In this prospective study, 123 healthy army draftees were subjected to CIH (5 days at 3,550 m, 2 days at sea level) for 6 months. In 100 study participants with complete data, ADMA, symmetric dimethylarginine (SDMA), L-arginine, arterial oxygen saturation (SaO2), systemic blood pressure, and hematocrit were assessed at months 0 (sea level), 1, 4, and 6. Acclimatization to altitude was determined using the Lake Louise Score (LLS) and the presence of acute mountain sickness (AMS). Echocardiography was performed after 6 months of CIH in 43 individuals with either good (n = 23) or poor (n = 20) acclimatization. Results: SaO2 acutely decreased at altitude and plateaued at 90% thereafter. ADMA increased and SDMA decreased during the study course. The incidence of AMS and the LLS was high after the first ascent (53 and 3.1 ± 2.4) and at 1 month of CIH (47 and 3.0 ± 2.6), but decreased to 20 and 1.4 ± 2.0 at month 6 (both p < 0.001). Eighteen participants (42%) showed a mean pulmonary arterial pressure (mPAP) >25 mm Hg, out of which 9 (21%) were classified as HAPH (mPAP ≥ 30 mm Hg). ADMA at sea level was significantly associated with mPAP at high altitude in month 6 (R = 0.413; p = 0.007). In ROC analysis, a cutoff for baseline ADMA of 0.665 μmol/L was determined to predict HAPH (mPAP > 30 mm Hg) with a sensitivity of 100% and a specificity of 63.6%. Conclusions: ADMA concentration increases during CIH. ADMA at sea level is an independent predictive biomarker of HAPH. SDMA concentration decreases during CIH and shows no association with HAPH. Our data support a role of impaired NO-mediated pulmonary vasodilation in the pathogenesis of HAPH." @default.
• W2944537177 created "2019-05-16" @default.
• W2944537177 creator A5007316785 @default.
• W2944537177 creator A5008875543 @default.
• W2944537177 creator A5024002940 @default.
• W2944537177 creator A5038106053 @default.
• W2944537177 creator A5057764662 @default.
• W2944537177 creator A5076697398 @default.
• W2944537177 creator A5076951981 @default.
• W2944537177 creator A5085550237 @default.
• W2944537177 date "2019-05-27" @default.
• W2944537177 modified "2023-10-14" @default.
• W2944537177 title "Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude" @default.
• W2944537177 cites W1583601846 @default.
• W2944537177 cites W1780987971 @default.
• W2944537177 cites W1905363631 @default.
• W2944537177 cites W1978784384 @default.
• W2944537177 cites W1986656566 @default.
• W2944537177 cites W1994586354 @default.
• W2944537177 cites W2000069831 @default.
• W2944537177 cites W2005587846 @default.
• W2944537177 cites W2008201148 @default.
• W2944537177 cites W2008977422 @default.
• W2944537177 cites W2024077658 @default.
• W2944537177 cites W2028833726 @default.
• W2944537177 cites W2033719921 @default.
• W2944537177 cites W2039194212 @default.
• W2944537177 cites W2041223323 @default.
• W2944537177 cites W2042800607 @default.
• W2944537177 cites W2051152628 @default.
• W2944537177 cites W2053354541 @default.
• W2944537177 cites W2058385357 @default.
• W2944537177 cites W2076680300 @default.
• W2944537177 cites W2084280040 @default.
• W2944537177 cites W2088632030 @default.
• W2944537177 cites W2091107957 @default.
• W2944537177 cites W2104168812 @default.
• W2944537177 cites W2105082749 @default.
• W2944537177 cites W2114138165 @default.
• W2944537177 cites W2136960413 @default.
• W2944537177 cites W2137708021 @default.
• W2944537177 cites W2143954917 @default.
• W2944537177 cites W2148531805 @default.
• W2944537177 cites W2151555731 @default.
• W2944537177 cites W2154388708 @default.
• W2944537177 cites W2157261119 @default.
• W2944537177 cites W2161370807 @default.
• W2944537177 cites W2165836510 @default.
• W2944537177 cites W2187630416 @default.
• W2944537177 cites W2328664855 @default.
• W2944537177 cites W2399470175 @default.
• W2944537177 cites W2416411972 @default.
• W2944537177 cites W2464014196 @default.
• W2944537177 cites W2556310017 @default.
• W2944537177 cites W2584358852 @default.
• W2944537177 cites W2602136859 @default.
• W2944537177 cites W2607031541 @default.
• W2944537177 cites W2610752749 @default.
• W2944537177 cites W2614118718 @default.
• W2944537177 cites W2755286805 @default.
• W2944537177 cites W2769062872 @default.
• W2944537177 cites W2790714911 @default.
• W2944537177 cites W2795146597 @default.
• W2944537177 cites W342717187 @default.
• W2944537177 cites W4238250933 @default.
• W2944537177 doi "https://doi.org/10.3389/fphys.2019.00651" @default.
• W2944537177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6545974" @default.
• W2944537177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31191349" @default.
• W2944537177 hasPublicationYear "2019" @default.
• W2944537177 type Work @default.
• W2944537177 sameAs 2944537177 @default.
• W2944537177 citedByCount "19" @default.
• W2944537177 countsByYear W29445371772020 @default.
• W2944537177 countsByYear W29445371772021 @default.
• W2944537177 countsByYear W29445371772022 @default.
• W2944537177 countsByYear W29445371772023 @default.
• W2944537177 crossrefType "journal-article" @default.
• W2944537177 hasAuthorship W2944537177A5007316785 @default.
• W2944537177 hasAuthorship W2944537177A5008875543 @default.
• W2944537177 hasAuthorship W2944537177A5024002940 @default.
• W2944537177 hasAuthorship W2944537177A5038106053 @default.
• W2944537177 hasAuthorship W2944537177A5057764662 @default.
• W2944537177 hasAuthorship W2944537177A5076697398 @default.
• W2944537177 hasAuthorship W2944537177A5076951981 @default.
• W2944537177 hasAuthorship W2944537177A5085550237 @default.
• W2944537177 hasBestOaLocation W29445371771 @default.
• W2944537177 hasConcept C105702510 @default.
• W2944537177 hasConcept C119406331 @default.
• W2944537177 hasConcept C126322002 @default.
• W2944537177 hasConcept C164705383 @default.
• W2944537177 hasConcept C178790620 @default.
• W2944537177 hasConcept C185592680 @default.
• W2944537177 hasConcept C18903297 @default.
• W2944537177 hasConcept C2777468819 @default.
• W2944537177 hasConcept C2778039513 @default.
• W2944537177 hasConcept C2779877776 @default.
• W2944537177 hasConcept C2780930700 @default.
• W2944537177 hasConcept C2780959883 @default.
• W2944537177 hasConcept C515207424 @default.
• W2944537177 hasConcept C540031477 @default.

• next