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- W2944543816 abstract ": Therapeutic hypothermia has consistently been shown to be a robust neuroprotectant in many labs studying different models of neurological disease. Although this therapy has shown great promise, there are still challenges at the clinical level that limit the ability to apply this routinely to each pathological condition. In order to overcome issues involved in hypothermia therapy, understanding of this attractive therapy is needed. We review methodological concerns surrounding therapeutic hypothermia, introduce the current status of therapeutic cooling in various acute brain insults, and review the literature surrounding the many underlying molecular mechanisms of hypothermic neuroprotection. Because recent work has shown that body temperature can be safely lowered using pharmacological approaches, this method may be an especially attractive option for many clinical applications. Since hypothermia can affect multiple aspects of brain pathophysiology, therapeutic hypothermia could also be considered a neuroprotection model in basic research, which would be used to identify potential therapeutic targets. We discuss how research in this area carries the potential to improve outcome from various acute neurological disorders." @default.
- W2944543816 created "2019-05-16" @default.
- W2944543816 creator A5016571028 @default.
- W2944543816 creator A5035167402 @default.
- W2944543816 creator A5043729394 @default.
- W2944543816 creator A5075739527 @default.
- W2944543816 date "2019-10-26" @default.
- W2944543816 modified "2023-10-12" @default.
- W2944543816 title "Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease" @default.
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