FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944550104> ?p ?o ?g. }

• W2944550104 endingPage "99" @default.
• W2944550104 startingPage "91" @default.
• W2944550104 abstract "Nucleic acid delivery to the eye is a promising treatment strategy for many retinal disorders. In this manuscript, retinal gene delivery with non-coated and chondroitin sulphate (CS) coated amphipathic and cationic peptides was tested. The transfection and gene knockdown efficiencies were evaluated in different retinal pigment epithelial (RPE) cell models including both dividing and differentiated cells. In addition, the mobility of peptide-based gene delivery systems was examined in porcine vitreous by particle tracking analysis. The results indicate that amphipathic and cationic peptides are safe in vitro and are capable of high transgene expression and gene knockdown in dividing cells. We further demonstrate that incorporation of CS improves the efficiency of gene delivery of peptide-based systems. Most importantly, the transgene expression mediated by both non-coated and CS coated peptides was high in differentiated as well as in human primary RPE cells which are typically difficult to transfect. Coating of peptide-based gene delivery systems with CS improved diffusion in the vitreous and enhanced the stability of the polyplexes. The results indicate that a peptide-based system can be fine-tuned as a promising approach for retinal gene delivery." @default.
• W2944550104 created "2019-05-16" @default.
• W2944550104 creator A5001465153 @default.
• W2944550104 creator A5012502846 @default.
• W2944550104 creator A5014958903 @default.
• W2944550104 creator A5042156204 @default.
• W2944550104 creator A5077190065 @default.
• W2944550104 creator A5088548378 @default.
• W2944550104 creator A5091424033 @default.
• W2944550104 date "2019-07-01" @default.
• W2944550104 modified "2023-10-09" @default.
• W2944550104 title "Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier" @default.
• W2944550104 cites W147942011 @default.
• W2944550104 cites W1553154837 @default.
• W2944550104 cites W1741672250 @default.
• W2944550104 cites W1964002661 @default.
• W2944550104 cites W1968284148 @default.
• W2944550104 cites W1975212218 @default.
• W2944550104 cites W1985307250 @default.
• W2944550104 cites W1986141440 @default.
• W2944550104 cites W1987163952 @default.
• W2944550104 cites W1997096535 @default.
• W2944550104 cites W1999868277 @default.
• W2944550104 cites W2003414091 @default.
• W2944550104 cites W2005025849 @default.
• W2944550104 cites W2013156289 @default.
• W2944550104 cites W2030482221 @default.
• W2944550104 cites W2039887117 @default.
• W2944550104 cites W2051674342 @default.
• W2944550104 cites W2053873441 @default.
• W2944550104 cites W2062815728 @default.
• W2944550104 cites W2066148691 @default.
• W2944550104 cites W2071167287 @default.
• W2944550104 cites W2073026167 @default.
• W2944550104 cites W2079159055 @default.
• W2944550104 cites W2079536804 @default.
• W2944550104 cites W2097975939 @default.
• W2944550104 cites W2139257010 @default.
• W2944550104 cites W2160167739 @default.
• W2944550104 cites W2256184428 @default.
• W2944550104 cites W2319743119 @default.
• W2944550104 cites W2326022816 @default.
• W2944550104 cites W2331576061 @default.
• W2944550104 cites W2529253831 @default.
• W2944550104 cites W2567292819 @default.
• W2944550104 cites W2580644607 @default.
• W2944550104 cites W2772353386 @default.
• W2944550104 cites W2785770604 @default.
• W2944550104 cites W2787945847 @default.
• W2944550104 cites W2804973939 @default.
• W2944550104 cites W2866567699 @default.
• W2944550104 doi "https://doi.org/10.1016/j.ejpb.2019.05.003" @default.
• W2944550104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31085311" @default.
• W2944550104 hasPublicationYear "2019" @default.
• W2944550104 type Work @default.
• W2944550104 sameAs 2944550104 @default.
• W2944550104 citedByCount "8" @default.
• W2944550104 countsByYear W29445501042020 @default.
• W2944550104 countsByYear W29445501042021 @default.
• W2944550104 countsByYear W29445501042022 @default.
• W2944550104 countsByYear W29445501042023 @default.
• W2944550104 crossrefType "journal-article" @default.
• W2944550104 hasAuthorship W2944550104A5001465153 @default.
• W2944550104 hasAuthorship W2944550104A5012502846 @default.
• W2944550104 hasAuthorship W2944550104A5014958903 @default.
• W2944550104 hasAuthorship W2944550104A5042156204 @default.
• W2944550104 hasAuthorship W2944550104A5077190065 @default.
• W2944550104 hasAuthorship W2944550104A5088548378 @default.
• W2944550104 hasAuthorship W2944550104A5091424033 @default.
• W2944550104 hasConcept C102230213 @default.
• W2944550104 hasConcept C104317684 @default.
• W2944550104 hasConcept C111599444 @default.
• W2944550104 hasConcept C12554922 @default.
• W2944550104 hasConcept C135983454 @default.
• W2944550104 hasConcept C153911025 @default.
• W2944550104 hasConcept C173396325 @default.
• W2944550104 hasConcept C185592680 @default.
• W2944550104 hasConcept C24107716 @default.
• W2944550104 hasConcept C2776929087 @default.
• W2944550104 hasConcept C2777343594 @default.
• W2944550104 hasConcept C2778024200 @default.
• W2944550104 hasConcept C2779281246 @default.
• W2944550104 hasConcept C2780827179 @default.
• W2944550104 hasConcept C54009773 @default.
• W2944550104 hasConcept C55493867 @default.
• W2944550104 hasConcept C86803240 @default.
• W2944550104 hasConcept C95444343 @default.
• W2944550104 hasConceptScore W2944550104C102230213 @default.
• W2944550104 hasConceptScore W2944550104C104317684 @default.
• W2944550104 hasConceptScore W2944550104C111599444 @default.
• W2944550104 hasConceptScore W2944550104C12554922 @default.
• W2944550104 hasConceptScore W2944550104C135983454 @default.
• W2944550104 hasConceptScore W2944550104C153911025 @default.
• W2944550104 hasConceptScore W2944550104C173396325 @default.
• W2944550104 hasConceptScore W2944550104C185592680 @default.
• W2944550104 hasConceptScore W2944550104C24107716 @default.
• W2944550104 hasConceptScore W2944550104C2776929087 @default.
• W2944550104 hasConceptScore W2944550104C2777343594 @default.

• next