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• W2944565286 abstract "Abstract Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death. Therefore, here, we investigate the mechanism of caspase-1-initiated cell death in GSDMD-deficient cells. Inflammasome stimuli induce apoptosis accompanied by caspase-3 activation in GSDMD-deficient macrophages, which largely relies on caspase-1. Chemical dimerization of caspase-1 induces pyroptosis in GSDMD-sufficient cells, but apoptosis in GSDMD-deficient cells. Caspase-1-induced apoptosis involves the Bid-caspase-9-caspase-3 axis, which can be followed by GSDME-dependent secondary necrosis/pyroptosis. However, Bid ablation does not completely abolish the cell death, suggesting the existence of an additional mechanism. Furthermore, cortical neurons and mast cells exhibit little or low GSDMD expression and undergo apoptosis after oxygen glucose deprivation and nigericin stimulation, respectively, in a caspase-1- and Bid-dependent manner. This study clarifies the molecular mechanism and biological roles of caspase-1-induced apoptosis in GSDMD-low/null cell types." @default.
• W2944565286 created "2019-05-16" @default.
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• W2944565286 date "2019-05-07" @default.
• W2944565286 modified "2023-10-12" @default.
• W2944565286 title "Caspase-1 initiates apoptosis in the absence of gasdermin D" @default.
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• W2944565286 doi "https://doi.org/10.1038/s41467-019-09753-2" @default.
• W2944565286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6505044" @default.
• W2944565286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31064994" @default.
• W2944565286 hasPublicationYear "2019" @default.
• W2944565286 type Work @default.
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