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- W2944565972 abstract "Abstract Background Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. Methods We investigated 186 children who were followed up regularly at the clinic for 4 years in a birth cohort study. The children were classified into three groups: early-onset eczema ( Results A significantly higher prevalence of sensitization to food, especially milk was observed in children with early-onset eczema compared with those without eczema at age 1, 1.5, 2, 3, and 4 years. Furthermore, a significantly higher number of eosinophils was detected in children with early or late-onset eczema at the age of 1.5 years. Both the early- and late-onset eczema were significantly associated with a higher prevalence of allergic rhinitis at age 2, 3, and 4 years, and asthma at age 2. Moreover, the early-onset eczema group showed a significantly increased risk of allergic rhinitis (P = 0.010) and asthma (P = 0.032) at age 4. Conclusion The children with early-onset eczema (" @default.
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- W2944565972 date "2020-12-01" @default.
- W2944565972 modified "2023-09-27" @default.
- W2944565972 title "Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood" @default.
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- W2944565972 doi "https://doi.org/10.1016/j.jmii.2019.04.007" @default.
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