FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944582486> ?p ?o ?g. }

• W2944582486 abstract "ABSTRACT Ion movements across biological membranes, driven by electrochemical gradients or active transport mechanisms, control essential cell functions. Membrane ion movements can manifest as electrogenic currents or electroneutral fluxes, and either process can alter the extracellular and/or intracellular concentration of the transported ion(s). Classical electrophysiological methods allow accurate measurement of membrane ion movements when the transport mechanism produces a net ionic current; however, they cannot directly measure electroneutral fluxes and do not detect any accompanying change in intracellular ion concentrations. Here, we developed a method for simultaneously measuring ion movements and the accompanying dynamic changes in intracellular ion concentration(s) in intact skeletal muscle fibers under voltage– or current clamp in real time. The method combines a two-microelectrode voltage-clamp with ion-selective and reference microelectrodes (4 electrode system). We validate the electrical stability of the system and the viability of the preparation for periods of approximately 1 h. We demonstrate the power of this method with measurements of intracellular Cl - , H + , and Na + to show: 1) voltage-dependent redistribution of Cl - ions; 2) intracellular pH changes induced by changes in extracellular pCO 2 ; and 3) electroneutral and electrogenic Na + movements controlled by the Na,K-ATPase. The method is useful for studying a range of transport mechanisms in many cell types, particularly when the transmembrane ion movements are electrically silent and/or when the transport activity measurably changes the intracellular activity of a transported ion." @default.
• W2944582486 created "2019-05-16" @default.
• W2944582486 creator A5039090382 @default.
• W2944582486 creator A5076565790 @default.
• W2944582486 creator A5082619971 @default.
• W2944582486 date "2019-05-11" @default.
• W2944582486 modified "2023-09-23" @default.
• W2944582486 title "A Four Electrode Method to Study Dynamics of Ion Activity and Transport in Skeletal Muscle Fibers" @default.
• W2944582486 cites W1574896699 @default.
• W2944582486 cites W2033843507 @default.
• W2944582486 cites W2037962705 @default.
• W2944582486 cites W2040517313 @default.
• W2944582486 cites W2042531992 @default.
• W2944582486 cites W2043747964 @default.
• W2944582486 cites W2049767847 @default.
• W2944582486 cites W2063412263 @default.
• W2944582486 cites W2109028568 @default.
• W2944582486 cites W2137861536 @default.
• W2944582486 cites W2158374815 @default.
• W2944582486 cites W2221404063 @default.
• W2944582486 cites W2497951911 @default.
• W2944582486 cites W2790249235 @default.
• W2944582486 cites W2991897012 @default.
• W2944582486 cites W3006482215 @default.
• W2944582486 cites W958091135 @default.
• W2944582486 doi "https://doi.org/10.1101/635490" @default.
• W2944582486 hasPublicationYear "2019" @default.
• W2944582486 type Work @default.
• W2944582486 sameAs 2944582486 @default.
• W2944582486 citedByCount "0" @default.
• W2944582486 crossrefType "posted-content" @default.
• W2944582486 hasAuthorship W2944582486A5039090382 @default.
• W2944582486 hasAuthorship W2944582486A5076565790 @default.
• W2944582486 hasAuthorship W2944582486A5082619971 @default.
• W2944582486 hasBestOaLocation W29445824861 @default.
• W2944582486 hasConcept C100837961 @default.
• W2944582486 hasConcept C111670793 @default.
• W2944582486 hasConcept C113196181 @default.
• W2944582486 hasConcept C12554922 @default.
• W2944582486 hasConcept C134897140 @default.
• W2944582486 hasConcept C145148216 @default.
• W2944582486 hasConcept C147789679 @default.
• W2944582486 hasConcept C169760540 @default.
• W2944582486 hasConcept C170493617 @default.
• W2944582486 hasConcept C17525397 @default.
• W2944582486 hasConcept C178790620 @default.
• W2944582486 hasConcept C181911157 @default.
• W2944582486 hasConcept C185263204 @default.
• W2944582486 hasConcept C185592680 @default.
• W2944582486 hasConcept C2777151030 @default.
• W2944582486 hasConcept C28406088 @default.
• W2944582486 hasConcept C41625074 @default.
• W2944582486 hasConcept C43617362 @default.
• W2944582486 hasConcept C50254741 @default.
• W2944582486 hasConcept C55493867 @default.
• W2944582486 hasConcept C79879829 @default.
• W2944582486 hasConcept C86803240 @default.
• W2944582486 hasConcept C99975950 @default.
• W2944582486 hasConceptScore W2944582486C100837961 @default.
• W2944582486 hasConceptScore W2944582486C111670793 @default.
• W2944582486 hasConceptScore W2944582486C113196181 @default.
• W2944582486 hasConceptScore W2944582486C12554922 @default.
• W2944582486 hasConceptScore W2944582486C134897140 @default.
• W2944582486 hasConceptScore W2944582486C145148216 @default.
• W2944582486 hasConceptScore W2944582486C147789679 @default.
• W2944582486 hasConceptScore W2944582486C169760540 @default.
• W2944582486 hasConceptScore W2944582486C170493617 @default.
• W2944582486 hasConceptScore W2944582486C17525397 @default.
• W2944582486 hasConceptScore W2944582486C178790620 @default.
• W2944582486 hasConceptScore W2944582486C181911157 @default.
• W2944582486 hasConceptScore W2944582486C185263204 @default.
• W2944582486 hasConceptScore W2944582486C185592680 @default.
• W2944582486 hasConceptScore W2944582486C2777151030 @default.
• W2944582486 hasConceptScore W2944582486C28406088 @default.
• W2944582486 hasConceptScore W2944582486C41625074 @default.
• W2944582486 hasConceptScore W2944582486C43617362 @default.
• W2944582486 hasConceptScore W2944582486C50254741 @default.
• W2944582486 hasConceptScore W2944582486C55493867 @default.
• W2944582486 hasConceptScore W2944582486C79879829 @default.
• W2944582486 hasConceptScore W2944582486C86803240 @default.
• W2944582486 hasConceptScore W2944582486C99975950 @default.
• W2944582486 hasLocation W29445824861 @default.
• W2944582486 hasLocation W29445824862 @default.
• W2944582486 hasOpenAccess W2944582486 @default.
• W2944582486 hasPrimaryLocation W29445824861 @default.
• W2944582486 hasRelatedWork W133920647 @default.
• W2944582486 hasRelatedWork W153431725 @default.
• W2944582486 hasRelatedWork W1994236043 @default.
• W2944582486 hasRelatedWork W2000458499 @default.
• W2944582486 hasRelatedWork W2019013376 @default.
• W2944582486 hasRelatedWork W2022753918 @default.
• W2944582486 hasRelatedWork W2036209456 @default.
• W2944582486 hasRelatedWork W2037717515 @default.
• W2944582486 hasRelatedWork W2038031117 @default.
• W2944582486 hasRelatedWork W2043000110 @default.
• W2944582486 hasRelatedWork W2056519016 @default.
• W2944582486 hasRelatedWork W205752564 @default.
• W2944582486 hasRelatedWork W2071591530 @default.
• W2944582486 hasRelatedWork W2072830920 @default.
• W2944582486 hasRelatedWork W2125809218 @default.

• next