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- W2944605450 abstract "Several new discoveries over the past decade have shown that metabolic syndrome, a cluster of metabolic disorders, including increased visceral obesity, hyperglycemia, hypertension, dyslipidemia and low HDL-cholesterol, is commonly associated with skeletal muscle insulin resistance. More recently, non-alcoholic fatty liver disease (NAFLD) was recognized as an additional condition that is strongly associated with features of metabolic syndrome. While the pathogenesis of skeletal muscle insulin resistance and fatty liver is multifactorial, the role of dysregulated redox signaling has been clearly demonstrated in the regulation of skeletal muscle insulin resistance and NAFLD. In this review, we aim to provide recent updates on redox regulation with respect to (a) pro-oxidant enzymes (e.g. NAPDH oxidase and xanthine oxidase); (b) mitochondrial dysfunction; (c) endoplasmic reticulum (ER) stress; (d) iron metabolism derangements; and (e) gut-skeletal muscle or gut-liver connection in the development of skeletal muscle insulin resistance and NAFLD. Furthermore, we discuss promising new therapeutic strategies targeting redox regulation currently under investigation for the treatment of skeletal muscle insulin resistance and NAFLD." @default.
- W2944605450 created "2019-05-16" @default.
- W2944605450 creator A5024721601 @default.
- W2944605450 creator A5045461759 @default.
- W2944605450 date "2019-06-01" @default.
- W2944605450 modified "2023-10-14" @default.
- W2944605450 title "Redox regulation of metabolic syndrome: recent developments in skeletal muscle insulin resistance and non-alcoholic fatty liver disease (NAFLD)" @default.
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- W2944605450 doi "https://doi.org/10.1016/j.cophys.2019.05.003" @default.
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