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• W2944711745 abstract "Extracellular vesicles (EVs) are known to contain unique proteins that reflect the cells of origins. Activated T cells are reported to secrete various EVs. To establish T cell subset-specific biomarkers, we performed proteomic analysis with Th1- and Th2-derived EVs and identified HLA-DR as a Th1-dominated EV membrane protein. We designed a measurement system for CD3 + CD4 + , CD3 + CD8 + , and CD3 + HLA-DR + EVs to specifically determine EV subpopulations derived from CD4 + , CD8 + , and Th1-type T cells, respectively. In vitro analysis showed that CD3 + CD4 + EVs and CD3 + CD8 + EVs were selectively secreted from activated CD4 + and CD8 + T cells, respectively, and that CD3 + HLA-DR + EVs were actively secreted from not only Th1 but also activated CD8 + T (probably mostly Tc1) cells. To evaluate the clinical usefulness of these EVs, we measured the serum levels in patients with inflammatory diseases, including Epstein-Barr virus (EBV,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:math>) infection, atopic dermatitis (AD,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:math>), rheumatoid arthritis (RA,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:math>), and osteoarthritis (OA,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:math>) and compared the levels with those of healthy adults (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:math>). CD3 + CD4 + EVs were significantly higher in all of EBV infection, AD, RA, and OA while CD3 + CD8 + EVs were higher in EBV infection, lower in RA, and not different in AD and OA relative to the control. The levels of CD3 + HLA-DR + EVs were markedly higher in EBV infection and significantly lower in AD. The results suggest that these EV subpopulations reflect in vivo activation status of total CD4 + , total CD8 + , and Th1/Tc1-type T cells, respectively, and may be helpful in T cell-related clinical settings, such as cancer immunotherapy and treatment of chronic infection, autoimmune diseases, and graft-versus-host disease." @default.
• W2944711745 created "2019-05-16" @default.
• W2944711745 creator A5005253419 @default.
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• W2944711745 date "2019-05-08" @default.
• W2944711745 modified "2023-10-14" @default.
• W2944711745 title "Circulating CD3⁺HLA-DR⁺Extracellular Vesicles as a Marker for Th1/Tc1-Type Immune Responses" @default.
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• W2944711745 doi "https://doi.org/10.1155/2019/6720819" @default.
• W2944711745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6530242" @default.
• W2944711745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31205958" @default.
• W2944711745 hasPublicationYear "2019" @default.
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