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• W2944735145 abstract "To investigate the effect of curcumin on dopamine neurons in Parkinson's disease (PD) and its mechanism.SH-SY5Y human neuroblastoma cells were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to establish the PD cell model. The model cells were treated with curcumin and/or autophagy inhibitor 3-MA. After 48 h of drug treatment, the number of surviving dopamine neurons was detected by tyrosine hydroxylase immunofluorescence method. Western blotting was used to detect protein expression of α-Synuclein (α-Syn), transcription factor EB (TFEB) and autophagy-related proteins lysosome-associated membrane protein 2A (LAMP2A) and microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ); RT-PCR was used to detect mRNA expression of α-Syn.Compared with MPTP model group, curcumin increased the number of surviving dopamine neurons(P<0.01), decreased both protein expression and mRNA expression of α-Syn (all P<0.01), and increased protein expression of TFEB, LAMP2A and LC3-Ⅱ (all P<0.01). When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-Ⅱ increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of α-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-Ⅱ decreased compared with curcumin group (all P<0.05).Curcumin exerts protective effect on dopamine neurons in PD, which may be associated with enhancing autophagy and promoting the clearance of α-Syn." @default.
• W2944735145 created "2019-05-16" @default.
• W2944735145 creator A5014763151 @default.
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• W2944735145 date "2018-05-25" @default.
• W2944735145 modified "2023-09-23" @default.
• W2944735145 title "[Protective effect of curcumin on dopamine neurons in Parkinson's disease and its mechanism]." @default.
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• W2944735145 doi "https://doi.org/10.3785/j.issn.1008-9292.2018.10.06" @default.
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