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• W2944735768 abstract "BackgroundCCAAT/enhancer binding protein delta (C/EBPδ,CEBPD), a gene part of the highly conserved basic-leucine zipper (b-ZIP) domain of transcriptional factors, is downregulated in 65% of high grade serous carcinomas of the ovary (HGSC). Overexpression of C/EBPδ in different tumours, such as glioblastoma and breast cancer either promotes tumour progression or inhibits growth and has low expression in normal tissue until activated by cytotoxic stressors.MethodsHigher overall expression of C/EBPδ in the luteal phase of the menstrual cycle prompted us to investigate the role of C/EBPδ in carcinogenesis. In vitro experiments were conducted in fallopian tube cell samples and cancer cell lines to investigate the role of C/EBPδ in proliferation, migration, and the epithelial to mesenchymal transition.FindingsExpression of C/EBPδ induced premature cellular arrest and decreased soft agar colony formation. Loss of C/EBPδ in epithelial cancer cell lines did not have significant effects on proliferation, yet overexpression demonstrated downregulation of growth, similar to normal fallopian tube cells. C/EBPδ promoted a partial mesenchymal to epithelial (MET) phenotype by upregulating E-cadherin and downregulating Vimentin and N-cadherin in FTE cells and increased migratory activity, which suggests a regulatory role in the epithelial-mesenchymal plasticity of these cells.InterpretationOur findings suggest that C/EBPδ regulates the phenotype of normal fallopian tube cells by acting on downstream regulatory factors that are implicated in the development of ovarian serous carcinogenesis.FundThis study was funded by the CDMRP Ovarian Cancer program (W81WH-0701-0371, W81XWH-18-1-0072), the Princess Margaret Cancer Centre Foundation, Foundation for Women's Cancer – The Belinda-Sue/Mary-Jane Walker Fund, Colleen's Dream Foundation and Sylvester Comprehensive Cancer Center." @default.
• W2944735768 created "2019-05-16" @default.
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• W2944735768 date "2019-06-01" @default.
• W2944735768 modified "2023-10-14" @default.
• W2944735768 title "CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma" @default.
• W2944735768 cites W1671745519 @default.
• W2944735768 cites W1889202581 @default.
• W2944735768 cites W1919979622 @default.
• W2944735768 cites W1938080407 @default.
• W2944735768 cites W1973253351 @default.
• W2944735768 cites W1977803522 @default.
• W2944735768 cites W1979391734 @default.
• W2944735768 cites W1980277782 @default.
• W2944735768 cites W1986010151 @default.
• W2944735768 cites W1989354370 @default.
• W2944735768 cites W1996990440 @default.
• W2944735768 cites W1998901985 @default.
• W2944735768 cites W1998992316 @default.
• W2944735768 cites W2008409590 @default.
• W2944735768 cites W2012975737 @default.
• W2944735768 cites W2016382281 @default.
• W2944735768 cites W2017152513 @default.
• W2944735768 cites W2017905687 @default.
• W2944735768 cites W2018023136 @default.
• W2944735768 cites W2023427912 @default.
• W2944735768 cites W2029803778 @default.
• W2944735768 cites W2033476275 @default.
• W2944735768 cites W2034613691 @default.
• W2944735768 cites W2036813463 @default.
• W2944735768 cites W2041634324 @default.
• W2944735768 cites W2042633087 @default.
• W2944735768 cites W2049518601 @default.
• W2944735768 cites W2050431144 @default.
• W2944735768 cites W2053263835 @default.
• W2944735768 cites W2061608421 @default.
• W2944735768 cites W2066441178 @default.
• W2944735768 cites W2071014344 @default.
• W2944735768 cites W2074157782 @default.
• W2944735768 cites W2082099893 @default.
• W2944735768 cites W2083430665 @default.
• W2944735768 cites W2084728801 @default.
• W2944735768 cites W2085225919 @default.
• W2944735768 cites W2092288031 @default.
• W2944735768 cites W2097486055 @default.
• W2944735768 cites W2108929261 @default.
• W2944735768 cites W2110265246 @default.
• W2944735768 cites W2111900617 @default.
• W2944735768 cites W2113679067 @default.
• W2944735768 cites W2116145684 @default.
• W2944735768 cites W2121333393 @default.
• W2944735768 cites W2123696077 @default.
• W2944735768 cites W2126426563 @default.
• W2944735768 cites W2129011493 @default.
• W2944735768 cites W2137005364 @default.
• W2944735768 cites W2144397374 @default.
• W2944735768 cites W2148014174 @default.
• W2944735768 cites W2149249471 @default.
• W2944735768 cites W2150769574 @default.
• W2944735768 cites W2152625770 @default.
• W2944735768 cites W2153009342 @default.
• W2944735768 cites W2154589460 @default.
• W2944735768 cites W2155222298 @default.
• W2944735768 cites W2162393230 @default.
• W2944735768 cites W2167201822 @default.
• W2944735768 cites W2292440129 @default.
• W2944735768 cites W2305551225 @default.
• W2944735768 cites W2327610860 @default.
• W2944735768 cites W2404828585 @default.
• W2944735768 cites W2417792191 @default.
• W2944735768 cites W2562173307 @default.
• W2944735768 cites W2563350820 @default.
• W2944735768 cites W2593355480 @default.
• W2944735768 cites W2733082701 @default.
• W2944735768 cites W2782172034 @default.
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• W2944735768 cites W2887788268 @default.
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• W2944735768 doi "https://doi.org/10.1016/j.ebiom.2019.05.002" @default.
• W2944735768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6603855" @default.
• W2944735768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31078521" @default.
• W2944735768 hasPublicationYear "2019" @default.
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