FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944801418> ?p ?o ?g. }

• W2944801418 abstract "Abstract Background This study investigated the effects of haplotypes T‐G and C‐A derived from NG_012836.1:g.4160T>C and NG_012836.1:g.4326G>A on protein expression levels in vitro and identified the functional sequence in the regulatory region of the GABRB3 gene linked to possible associations with schizophrenia. Methods Recombinant plasmids with haplotypes T‐G and C‐A and 10 recombinant vectors containing deletion fragments from the GABRB3 gene 5′ regulatory region were transfected into HEK‐293, SK‐N‐SH, and SH‐SY5Y cells. The relative fluorescence intensity of the two haplotypes and different sequences was compared using a dual luciferase reporter assay system. Results The relative fluorescence intensity of haplotype C‐A was significantly lower than that of T‐G. We shortened the core promoter sequence of the GABRB3 gene 5′ regulation region from −177 bp to −18 bp (ATG+1). We also found an expression suppression region from −1,735 bp to −1,638 bp and an enhanced regulatory region from −1,638 bp to −1,335 bp. Multiple inhibitory functional elements were identified in the region from −680 bp to −177 bp. Conclusion We demonstrated that haplotype C‐A might increase the risk of schizophrenia and found multiple regulatory regions that had an effect on GABRB3 receptor expression." @default.
• W2944801418 created "2019-05-16" @default.
• W2944801418 creator A5003490164 @default.
• W2944801418 creator A5008659449 @default.
• W2944801418 creator A5041411788 @default.
• W2944801418 creator A5048704331 @default.
• W2944801418 creator A5053798680 @default.
• W2944801418 creator A5056169325 @default.
• W2944801418 creator A5065954783 @default.
• W2944801418 creator A5080780749 @default.
• W2944801418 creator A5087790711 @default.
• W2944801418 date "2019-03-25" @default.
• W2944801418 modified "2023-09-25" @default.
• W2944801418 title "Functional analysis of haplotypes and promoter activity at the 5′ region of the human<i>GABRB3</i>gene and associations with schizophrenia" @default.
• W2944801418 cites W1483685331 @default.
• W2944801418 cites W1528717760 @default.
• W2944801418 cites W1607810874 @default.
• W2944801418 cites W1963673462 @default.
• W2944801418 cites W1967117492 @default.
• W2944801418 cites W1979219206 @default.
• W2944801418 cites W2011601996 @default.
• W2944801418 cites W2012436706 @default.
• W2944801418 cites W2043010186 @default.
• W2944801418 cites W2078980985 @default.
• W2944801418 cites W2117770051 @default.
• W2944801418 cites W2127650618 @default.
• W2944801418 cites W2137827045 @default.
• W2944801418 cites W2157700070 @default.
• W2944801418 cites W2161195087 @default.
• W2944801418 cites W2234802731 @default.
• W2944801418 cites W2279238409 @default.
• W2944801418 cites W2330845539 @default.
• W2944801418 cites W2560317598 @default.
• W2944801418 cites W2595135393 @default.
• W2944801418 cites W2773720443 @default.
• W2944801418 cites W2807744873 @default.
• W2944801418 cites W2809042666 @default.
• W2944801418 doi "https://doi.org/10.1002/mgg3.652" @default.
• W2944801418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6503024" @default.
• W2944801418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30908890" @default.
• W2944801418 hasPublicationYear "2019" @default.
• W2944801418 type Work @default.
• W2944801418 sameAs 2944801418 @default.
• W2944801418 citedByCount "1" @default.
• W2944801418 countsByYear W29448014182020 @default.
• W2944801418 crossrefType "journal-article" @default.
• W2944801418 hasAuthorship W2944801418A5003490164 @default.
• W2944801418 hasAuthorship W2944801418A5008659449 @default.
• W2944801418 hasAuthorship W2944801418A5041411788 @default.
• W2944801418 hasAuthorship W2944801418A5048704331 @default.
• W2944801418 hasAuthorship W2944801418A5053798680 @default.
• W2944801418 hasAuthorship W2944801418A5056169325 @default.
• W2944801418 hasAuthorship W2944801418A5065954783 @default.
• W2944801418 hasAuthorship W2944801418A5080780749 @default.
• W2944801418 hasAuthorship W2944801418A5087790711 @default.
• W2944801418 hasBestOaLocation W29448014181 @default.
• W2944801418 hasConcept C101762097 @default.
• W2944801418 hasConcept C104317684 @default.
• W2944801418 hasConcept C150194340 @default.
• W2944801418 hasConcept C153911025 @default.
• W2944801418 hasConcept C161733203 @default.
• W2944801418 hasConcept C165864922 @default.
• W2944801418 hasConcept C180754005 @default.
• W2944801418 hasConcept C197754878 @default.
• W2944801418 hasConcept C21592294 @default.
• W2944801418 hasConcept C22744801 @default.
• W2944801418 hasConcept C40767141 @default.
• W2944801418 hasConcept C54355233 @default.
• W2944801418 hasConcept C86803240 @default.
• W2944801418 hasConceptScore W2944801418C101762097 @default.
• W2944801418 hasConceptScore W2944801418C104317684 @default.
• W2944801418 hasConceptScore W2944801418C150194340 @default.
• W2944801418 hasConceptScore W2944801418C153911025 @default.
• W2944801418 hasConceptScore W2944801418C161733203 @default.
• W2944801418 hasConceptScore W2944801418C165864922 @default.
• W2944801418 hasConceptScore W2944801418C180754005 @default.
• W2944801418 hasConceptScore W2944801418C197754878 @default.
• W2944801418 hasConceptScore W2944801418C21592294 @default.
• W2944801418 hasConceptScore W2944801418C22744801 @default.
• W2944801418 hasConceptScore W2944801418C40767141 @default.
• W2944801418 hasConceptScore W2944801418C54355233 @default.
• W2944801418 hasConceptScore W2944801418C86803240 @default.
• W2944801418 hasFunder F4320321001 @default.
• W2944801418 hasFunder F4320324301 @default.
• W2944801418 hasIssue "5" @default.
• W2944801418 hasLocation W29448014181 @default.
• W2944801418 hasLocation W29448014182 @default.
• W2944801418 hasLocation W29448014183 @default.
• W2944801418 hasOpenAccess W2944801418 @default.
• W2944801418 hasPrimaryLocation W29448014181 @default.
• W2944801418 hasRelatedWork W2043622035 @default.
• W2944801418 hasRelatedWork W2057739137 @default.
• W2944801418 hasRelatedWork W2057875675 @default.
• W2944801418 hasRelatedWork W2060131368 @default.
• W2944801418 hasRelatedWork W2092584888 @default.
• W2944801418 hasRelatedWork W2111182449 @default.
• W2944801418 hasRelatedWork W2153071879 @default.
• W2944801418 hasRelatedWork W2161722978 @default.
• W2944801418 hasRelatedWork W2167465117 @default.
• W2944801418 hasRelatedWork W4244403405 @default.

• next