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- W2944803493 abstract "ABSTRACT Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV 1 : r g =0.098, p=2.3×10 −8 ) and the ratio of FEV 1 to forced vital capacity (FEV 1 /FVC: r g =0.137, p=2.0×10 −12 ). Mendelian randomization analyses demonstrate that reduced FEV 1 increases squamous cell carcinoma risk (odds ratio (OR)=1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV 1 /FVC increases the risk of adenocarcinoma (OR=1.17, 1.01-1.35) and lung cancer in never smokers (OR=1.56, 1.05-2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis." @default.
- W2944803493 created "2019-05-16" @default.
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- W2944803493 date "2019-05-11" @default.
- W2944803493 modified "2023-10-08" @default.
- W2944803493 title "Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility" @default.
- W2944803493 cites W130099911 @default.
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- W2944803493 cites W1883683241 @default.
- W2944803493 cites W1905058580 @default.
- W2944803493 cites W1967407054 @default.
- W2944803493 cites W1973523868 @default.
- W2944803493 cites W1983393049 @default.
- W2944803493 cites W1983897833 @default.
- W2944803493 cites W1996726906 @default.
- W2944803493 cites W2021085462 @default.
- W2944803493 cites W2030749349 @default.
- W2944803493 cites W2032311106 @default.
- W2944803493 cites W2039153962 @default.
- W2944803493 cites W2039675637 @default.
- W2944803493 cites W2053743600 @default.
- W2944803493 cites W2075396092 @default.
- W2944803493 cites W2076154138 @default.
- W2944803493 cites W2076731477 @default.
- W2944803493 cites W2092526634 @default.
- W2944803493 cites W2094269270 @default.
- W2944803493 cites W2102213696 @default.
- W2944803493 cites W2106779017 @default.
- W2944803493 cites W2108679807 @default.
- W2944803493 cites W2110846909 @default.
- W2944803493 cites W2118089746 @default.
- W2944803493 cites W2119729352 @default.
- W2944803493 cites W2125078269 @default.
- W2944803493 cites W2126411676 @default.
- W2944803493 cites W2129183735 @default.
- W2944803493 cites W2137291487 @default.
- W2944803493 cites W2137397912 @default.
- W2944803493 cites W2144058118 @default.
- W2944803493 cites W2145191876 @default.
- W2944803493 cites W2148351250 @default.
- W2944803493 cites W2153860431 @default.
- W2944803493 cites W2154583077 @default.
- W2944803493 cites W2166406579 @default.
- W2944803493 cites W2167704143 @default.
- W2944803493 cites W2169237347 @default.
- W2944803493 cites W2173603370 @default.
- W2944803493 cites W2232693424 @default.
- W2944803493 cites W2239931343 @default.
- W2944803493 cites W2324862792 @default.