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- W2944804521 abstract "Abstract The cerebellar granule cells (GrCs) form an anatomically homogeneous neuronal population which, in its canonical description, discharges regularly without adaptation. We show here that GrCs in fact generate diverse response patterns to current injection and synaptic activation, ranging from adaptation to acceleration of firing. Adaptation was predicted by parameter optimization in detailed GrC computational models based on the available knowledge on GrC ionic channels. The models also predicted that acceleration required the involvement of additional mechanisms. We found that yet unrecognized TRPM4 currents in accelerating GrCs could specifically account for firing acceleration. Moreover, adapting GrCs were better in transmitting high-frequency mossy fiber (MF) bursts over a background discharge than accelerating GrCs. This implied that different electroresponsive patterns corresponded to specific synaptic properties reflecting different neurotransmitter release probability. The correspondence of pre- and post-synaptic properties generated effective MF-GrC transmission channels, which could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage." @default.
- W2944804521 created "2019-05-16" @default.
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- W2944804521 date "2019-05-14" @default.
- W2944804521 modified "2023-09-28" @default.
- W2944804521 title "Parameter tuning differentiates granule cell subtypes enriching the repertoire of retransmission properties at the cerebellum input stage" @default.
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- W2944804521 doi "https://doi.org/10.1101/638247" @default.
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