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- W2944824367 abstract "The effect of intravenous administration of deamina-D-arginine vasopressin (DDAVP) and adrenaline an levels of factor VIII and plasminogen activator (PA) was studied. In normal subjects and mild haemophiliacs DDAVP caused a rise of plasma levels of PA, procoagulant factor VIII (V IIIC) and its antigen (VIIICAg), factor VIII related antigen (VIIIRAg) and ristacetin co-factor activity (VIIIRiCoF). Similarly in most patients with vWd (including those with VIIIRAg of increased electrophoretic mobility) an increase of PA and all FVIII activities was observed. In one patient with vWd (VIIIC 9u/dl, VIIICAg 13u/dl, VIIIRAg 3u/dl; VIIIRiCoF <3u/dl, bleeding time > 15 min.) in whom an inhibitor of VIIIRiCoF was excluded neither DDAVP nor adrenaline caused the expected rise of PA, VIIIRAg or VIIIRiCoF although VIIIC and VIIICAg were markedly increased. The bleeding times did not shorten. No rise of PA or VIII-related activities was observed after venous occlusion. The results suggest that in some patients with vWd there is defective synthesis/release of both VIIIRAg/VIIIRiCoF and PA. They are consistent with the presence of a primary endothelial cell defectin this disorder." @default.
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- W2944824367 date "1979-01-01" @default.
- W2944824367 modified "2023-09-23" @default.
- W2944824367 title "Factor VIII and Fibrinolytic Response to DDAVP and Adrenaline in Normal Subjects and Dissociate Response in Von Willebrand’s Disease" @default.
- W2944824367 doi "https://doi.org/10.1055/s-0039-1687265" @default.
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