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- W2944824748 abstract "Abstract Introduction The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods In a large‐scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross‐sectional differences, however, apolipoprotein E ε4 ( APOE ε4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion For the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions." @default.
- W2944824748 created "2019-05-29" @default.
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- W2944824748 date "2019-05-18" @default.
- W2944824748 modified "2023-10-10" @default.
- W2944824748 title "Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease" @default.
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- W2944824748 doi "https://doi.org/10.1016/j.jalz.2019.03.006" @default.
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