Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944870857> ?p ?o ?g. }
- W2944870857 abstract "ABSTRACT Chromosome structure is a crucial regulatory factor for a wide range of nuclear processes. Chromosome Conformation Capture (3C)-based experiments combined with computational modelling are pivotal for unveiling 3D chromosome structure. Here, we introduce TADdyn, a new tool that integrates time-course 3C data, restraint-based modelling, and molecular dynamics to simulate the structural rearrangements of genomic loci in a completely data-driven way. We applied TADdyn on in-situ Hi-C time-course experiments studying the reprogramming of murine B cells to pluripotent cells, and characterized the structural rearrangements that take place upon changes in the transcriptional state of 11 genomic loci. TADdyn simulations show that structural cages form around the transcription starting site of active loci to stabilize their dynamics, by initiating ( hit ) and maintaining ( stick ) interactions with regulatory regions. Consistent findings with TADdyn for all loci under study suggest that this hit-and-stick mechanism may represent a general mechanism to trigger and stabilize transcription." @default.
- W2944870857 created "2019-05-29" @default.
- W2944870857 creator A5016167138 @default.
- W2944870857 creator A5025424827 @default.
- W2944870857 creator A5039868300 @default.
- W2944870857 creator A5051979607 @default.
- W2944870857 creator A5082758634 @default.
- W2944870857 creator A5084274556 @default.
- W2944870857 creator A5090755680 @default.
- W2944870857 date "2019-05-20" @default.
- W2944870857 modified "2023-10-18" @default.
- W2944870857 title "Dynamic simulations of transcriptional control during cell reprogramming reveal spatial chromatin caging" @default.
- W2944870857 cites W1605145036 @default.
- W2944870857 cites W1631477095 @default.
- W2944870857 cites W1831401007 @default.
- W2944870857 cites W1970831058 @default.
- W2944870857 cites W1973062929 @default.
- W2944870857 cites W2004369921 @default.
- W2944870857 cites W2007898019 @default.
- W2944870857 cites W2009510163 @default.
- W2944870857 cites W2014862205 @default.
- W2944870857 cites W2018617695 @default.
- W2944870857 cites W2018626566 @default.
- W2944870857 cites W2019465613 @default.
- W2944870857 cites W2020977773 @default.
- W2944870857 cites W2037027640 @default.
- W2944870857 cites W2056482755 @default.
- W2944870857 cites W2058971275 @default.
- W2944870857 cites W2065577331 @default.
- W2944870857 cites W2070021921 @default.
- W2944870857 cites W2073026107 @default.
- W2944870857 cites W2073504534 @default.
- W2944870857 cites W2074915491 @default.
- W2944870857 cites W2081080458 @default.
- W2944870857 cites W2091548199 @default.
- W2944870857 cites W2096526406 @default.
- W2944870857 cites W2097798909 @default.
- W2944870857 cites W2098497185 @default.
- W2944870857 cites W2099034339 @default.
- W2944870857 cites W2101249563 @default.
- W2944870857 cites W2137601569 @default.
- W2944870857 cites W2153856160 @default.
- W2944870857 cites W2155859779 @default.
- W2944870857 cites W2161212572 @default.
- W2944870857 cites W2162261678 @default.
- W2944870857 cites W2162618509 @default.
- W2944870857 cites W2163412235 @default.
- W2944870857 cites W2169389191 @default.
- W2944870857 cites W2175853567 @default.
- W2944870857 cites W2253035633 @default.
- W2944870857 cites W2293954090 @default.
- W2944870857 cites W2295297857 @default.
- W2944870857 cites W2320440892 @default.
- W2944870857 cites W2332009504 @default.
- W2944870857 cites W2401568148 @default.
- W2944870857 cites W2462894283 @default.
- W2944870857 cites W2534494590 @default.
- W2944870857 cites W2557035210 @default.
- W2944870857 cites W2580178967 @default.
- W2944870857 cites W2593043670 @default.
- W2944870857 cites W2622774366 @default.
- W2944870857 cites W2707558812 @default.
- W2944870857 cites W2736242246 @default.
- W2944870857 cites W2738924259 @default.
- W2944870857 cites W2739458618 @default.
- W2944870857 cites W2762780517 @default.
- W2944870857 cites W2765567136 @default.
- W2944870857 cites W2767765629 @default.
- W2944870857 cites W2781764709 @default.
- W2944870857 cites W2782774915 @default.
- W2944870857 cites W2800968671 @default.
- W2944870857 cites W2807807965 @default.
- W2944870857 cites W2809057270 @default.
- W2944870857 cites W2809265915 @default.
- W2944870857 cites W2884101170 @default.
- W2944870857 cites W2888450764 @default.
- W2944870857 cites W2890836916 @default.
- W2944870857 cites W2911472928 @default.
- W2944870857 cites W2913116862 @default.
- W2944870857 cites W2914173303 @default.
- W2944870857 cites W2945038365 @default.
- W2944870857 cites W2945220048 @default.
- W2944870857 cites W2952052372 @default.
- W2944870857 cites W2952203741 @default.
- W2944870857 cites W4231020221 @default.
- W2944870857 doi "https://doi.org/10.1101/642009" @default.
- W2944870857 hasPublicationYear "2019" @default.
- W2944870857 type Work @default.
- W2944870857 sameAs 2944870857 @default.
- W2944870857 citedByCount "2" @default.
- W2944870857 countsByYear W29448708572020 @default.
- W2944870857 crossrefType "posted-content" @default.
- W2944870857 hasAuthorship W2944870857A5016167138 @default.
- W2944870857 hasAuthorship W2944870857A5025424827 @default.
- W2944870857 hasAuthorship W2944870857A5039868300 @default.
- W2944870857 hasAuthorship W2944870857A5051979607 @default.
- W2944870857 hasAuthorship W2944870857A5082758634 @default.
- W2944870857 hasAuthorship W2944870857A5084274556 @default.
- W2944870857 hasAuthorship W2944870857A5090755680 @default.
- W2944870857 hasBestOaLocation W29448708571 @default.