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- W2944877229 abstract "The aim of the present study was to investigate the detoxifying effects of aloe polysaccharide (APS), propolis, and the mixture of APS and propolis on the urinary excretion of major human tobacco carcinogens, BaP and an addictive stimulant alkaloid, nicotine. Smokers (≥20 cigarettes/day) were randomly classified into four subgroups (10 people/group) and were given 600 mg/day of APS, 600 mg/day of propolis, or 600 mg/day of the mixture of APS (420 mg/day) and propolis (180 mg/day) for four weeks. Urinary excretion of BaP and cotinine (a metabolite of nicotine) increased in a time-dependent manner increased after supplementation with APS (BaP, 2.23-fold; cotinine, 2.64-fold), propolis (BaP, 1.30-fold; cotinine, 2.08-fold), and the mixture (BaP, 2.33-fold; cotinine, 2.28-fold) compared with smoker control. Creatinine, glucose, and total bilirubin levels significantly decreased in a time-dependent manner after supplementation with APS (creatinine, 15.24%; glucose, 40.22%; total bilirubin, 48.82%), propolis (creatinine, 16.83%; glucose, 36.25%; total bilirubin, 52.59%), and the mixture (creatinine, 16.36%; glucose, 46.37%; total bilirubin, 39.20%) (p < 0.05). These results suggest that supplementation with APS, propolis, or the mixture could reduce the risk of cancer or other diseases associated with tobacco smoking by enhancing urinary excretion of BaP and nicotine." @default.
- W2944877229 created "2019-05-29" @default.
- W2944877229 creator A5035778076 @default.
- W2944877229 creator A5052433739 @default.
- W2944877229 creator A5058190632 @default.
- W2944877229 creator A5078731540 @default.
- W2944877229 date "2019-08-01" @default.
- W2944877229 modified "2023-10-16" @default.
- W2944877229 title "Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers" @default.
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- W2944877229 doi "https://doi.org/10.1016/j.fct.2019.05.029" @default.
- W2944877229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31112706" @default.
- W2944877229 hasPublicationYear "2019" @default.
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