FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2944902485> ?p ?o ?g. }

• W2944902485 endingPage "2370" @default.
• W2944902485 startingPage "2370" @default.
• W2944902485 abstract "Serotonin has important roles in the development of the brain and other organs. Manipulations of synaptic serotonin by drugs such as serotonin reuptake inhibitors (SRI) or serotonin norepinephrine reuptake inhibitors (SNRI) might alter their development and function. Of interest, most studies on the outcome of prenatal exposure to SRI in human have not found significant embryonic or fetal damage, except for a possible, slight increase in cardiac malformations. In up to a third of newborns exposed to SRI, exposure may induce transient neonatal behavioral changes (poor neonatal adaptation) and increased rate of persistent pulmonary hypertension. Prenatal SRI may also cause slight motor delay and language impairment but these are transient. The data on the possible association of prenatal SRIs with autism spectrum disorder (ASD) are inconsistent, and seem to be related to pre-pregnancy treatment or to maternal depression. Prenatal SRIs also appear to affect the hypothalamic hypophyseal adrenal (HPA) axis inducing epigenetic changes, but the long-term consequences of these effects on humans are as yet unknown. SRIs are metabolized in the liver by several cytochrome P450 (CYP) enzymes. Faster metabolism of most SRIs in late pregnancy leads to lower maternal concentrations, and thus potentially to decreased efficacy which is more prominent in women that are rapid metabolizers. Studies suggest that the serotonin transporter SLC6A4 promoter is associated with adverse neonatal outcomes after SRI exposure. Since maternal depression may adversely affect the child’s development, one has to consider the risk of SRI discontinuation on the fetus and the child. As with any drug treatment in pregnancy, the benefits to the mother should be considered versus the possible hazards to the developing embryo/fetus." @default.
• W2944902485 created "2019-05-29" @default.
• W2944902485 creator A5009871577 @default.
• W2944902485 creator A5021317983 @default.
• W2944902485 date "2019-05-14" @default.
• W2944902485 modified "2023-09-30" @default.
• W2944902485 title "SSRIs and SNRIs (SRI) in Pregnancy: Effects on the Course of Pregnancy and the Offspring: How Far Are We from Having All the Answers?" @default.
• W2944902485 cites W134356120 @default.
• W2944902485 cites W1441999666 @default.
• W2944902485 cites W1501448374 @default.
• W2944902485 cites W1501635529 @default.
• W2944902485 cites W1505951056 @default.
• W2944902485 cites W1506602199 @default.
• W2944902485 cites W1570432210 @default.
• W2944902485 cites W1618574694 @default.
• W2944902485 cites W1864226738 @default.
• W2944902485 cites W1866814291 @default.
• W2944902485 cites W1871144505 @default.
• W2944902485 cites W1885149309 @default.
• W2944902485 cites W1964280320 @default.
• W2944902485 cites W1964501103 @default.
• W2944902485 cites W1965963898 @default.
• W2944902485 cites W1966485207 @default.
• W2944902485 cites W1967261707 @default.
• W2944902485 cites W1971251420 @default.
• W2944902485 cites W1971729817 @default.
• W2944902485 cites W1977989261 @default.
• W2944902485 cites W1978522713 @default.
• W2944902485 cites W1978564006 @default.
• W2944902485 cites W1978691050 @default.
• W2944902485 cites W1983734682 @default.
• W2944902485 cites W1989830600 @default.
• W2944902485 cites W1990280908 @default.
• W2944902485 cites W1991458325 @default.
• W2944902485 cites W1992568187 @default.
• W2944902485 cites W1996291771 @default.
• W2944902485 cites W1998048384 @default.
• W2944902485 cites W1998820997 @default.
• W2944902485 cites W2003569891 @default.
• W2944902485 cites W2004928044 @default.
• W2944902485 cites W2009062709 @default.
• W2944902485 cites W2009259832 @default.
• W2944902485 cites W2009889141 @default.
• W2944902485 cites W2013822799 @default.
• W2944902485 cites W2013911855 @default.
• W2944902485 cites W2015924469 @default.
• W2944902485 cites W2019027336 @default.
• W2944902485 cites W2019056171 @default.
• W2944902485 cites W2023682546 @default.
• W2944902485 cites W2027747918 @default.
• W2944902485 cites W2030681980 @default.
• W2944902485 cites W2032234096 @default.
• W2944902485 cites W2032519777 @default.
• W2944902485 cites W2032573956 @default.
• W2944902485 cites W2032803475 @default.
• W2944902485 cites W2034948290 @default.
• W2944902485 cites W2037065704 @default.
• W2944902485 cites W2038598954 @default.
• W2944902485 cites W2039857111 @default.
• W2944902485 cites W2040939072 @default.
• W2944902485 cites W2047139732 @default.
• W2944902485 cites W2048933622 @default.
• W2944902485 cites W2048993716 @default.
• W2944902485 cites W2052092268 @default.
• W2944902485 cites W2053376505 @default.
• W2944902485 cites W2055121759 @default.
• W2944902485 cites W2061360351 @default.
• W2944902485 cites W2062240933 @default.
• W2944902485 cites W2062812406 @default.
• W2944902485 cites W2064612594 @default.
• W2944902485 cites W2070709934 @default.
• W2944902485 cites W2071055980 @default.
• W2944902485 cites W2072992689 @default.
• W2944902485 cites W2074924086 @default.
• W2944902485 cites W2076224650 @default.
• W2944902485 cites W2079507344 @default.
• W2944902485 cites W2082537352 @default.
• W2944902485 cites W2082717009 @default.
• W2944902485 cites W2084991563 @default.
• W2944902485 cites W2086694416 @default.
• W2944902485 cites W2095446576 @default.
• W2944902485 cites W2096203250 @default.
• W2944902485 cites W2097950119 @default.
• W2944902485 cites W2101485714 @default.
• W2944902485 cites W2105840567 @default.
• W2944902485 cites W2105930613 @default.
• W2944902485 cites W2106568812 @default.
• W2944902485 cites W2108194202 @default.
• W2944902485 cites W2109296281 @default.
• W2944902485 cites W2114200126 @default.
• W2944902485 cites W2114552474 @default.
• W2944902485 cites W2119119176 @default.
• W2944902485 cites W2120112515 @default.
• W2944902485 cites W2120734658 @default.
• W2944902485 cites W2124906668 @default.
• W2944902485 cites W2126236299 @default.
• W2944902485 cites W2129626993 @default.
• W2944902485 cites W2129701778 @default.

• next