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• W2944937890 abstract "The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent. Several studies have shown that a greater presence of TILs, especially brisk, in primary melanoma is associated with a better prognosis and higher survival rate.We investigated by enzyme-linked immunosorbent assay (ELISA) the correlation between PD-1 levels in plasma and the presence/absence of TILs in 28 patients with metastatic melanoma.Low plasma PD-1 levels were correlated with brisk TILs in primary melanoma, whereas intermediate values correlated with the nonbrisk TILs, and high PD-1 levels with absent TILs. Although the low number of samples did not allow us to obtain a statistically significant correlation between the plasma PD-1 levels and the patients' overall survival depending on the absence/presence of TILs, the median survival of patients having brisk type TILs was 5 months higher than that of patients with absent and nonbrisk TILs.This work highlights the ability of measuring the plasma PD-1 levels in order to predict the prognosis of patients with untreated metastatic melanoma without a BRAF mutation at the time of diagnosis." @default.
• W2944937890 created "2019-05-29" @default.
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• W2944937890 date "2019-01-01" @default.
• W2944937890 modified "2023-10-10" @default.
• W2944937890 title "Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?" @default.
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• W2944937890 doi "https://doi.org/10.1177/1758835919848872" @default.
• W2944937890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6535916" @default.
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• W2944937890 hasPublicationYear "2019" @default.
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