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- W2944993704 abstract "Microfluidic labs-on-chip have fueled the automation of biochemical protocols (assays) on a tiny device and found versatile applications to DNA analysis, medical diagnostics, forensics, and drug design. Sample preparation, which includes dilution of fluids or solution mixing, is needed as a preprocessing step for most of the assays. Although continuous-flow microfluidic biochips (CFMB) are being widely used by chemists and biologists, accurate sample preparation with them is a challenge and the technology lacks an automated CAD-tool that can be deployed to design the underlying fluidic network. In this paper, we present, the physical design of a 3D-fluidic network that can be used as a universal platform for dilution preparation. The network does not need any control-valve for fluid navigation or multiplexing, yet it is fully programmable. A sample with any given concentration factor (CF) can be produced as output-flow by controlling only the rate of input-fluid injection. Simulation with COMSOL Multiphysics Software shows that the proposed free-flowing CFMB outperforms prior approaches in achieving the accuracy of CFs and diversity of applications." @default.
- W2944993704 created "2019-05-29" @default.
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- W2944993704 date "2019-01-01" @default.
- W2944993704 modified "2023-09-26" @default.
- W2944993704 title "Design of Continuous-Flow Lab-on-Chip with 3D Microfluidic Network for Sample Preparation" @default.
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- W2944993704 doi "https://doi.org/10.1109/vlsid.2019.00052" @default.
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