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- W2944995250 abstract "The reactivity of potentially thromboresistant polymers was determined in sheep by measurement of the lifespan of Cr51-labelled platelets. Materials were tested as tubing (90-125 cm × 2.5-3 mm I.D.) interposed in a 7 cm silicone rubber carotid A.-ext. jugular V. shunt. Platelet lifespan decreased as the length of the basic silicone rubber shunt increased from 7 cm (“shunt control”, T½ 78.3 ± 11.6 S.D. hrs.; n = 18) to 50 cm (T½ 62.0 ± 7.5 hrs.; n=7; p< 0.001 vs. shunt control) but was longer than in sheep without a shunt (T½ 63.1 ± 11.2 hrs.; n=21; p<0.001 vs. shunt control), probably because of artifactual activation of platelets in blood sampling by needle puncture in the absence of a shunt. Of sixteen polymers studied in 42 sheep (n=117), all significantly shortened platelet lifespan except polyurethane (T½ 72.8 ± 12.1 hrs.; n=12) and non-cross-linked silica-free polydimethyl siloxane (T½ 69.8 ± 13.9 hrs.; n = 9). Polymethyl acrylate (PMA) (T½ 71.2 ± 5.4 hrs.; n=ll; p<0.04 vs. shunt control) was passivated by exposure to platelet free plasma before whole blood (T½ 90.3 ± 3.6 hrs.; n=5; ρ <0.05 vs. untreated PMA). Thus, the adsorbed film of plasma constituents has a lasting and decisive effect on thromboresistance of the surface. The long term behavior of an artificial surface may be dictated by the events of the first few seconds of blood-surface contact." @default.
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- W2944995250 date "1977-01-01" @default.
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- W2944995250 title "In Vivo Assessment of Thromboresistant Materials by Determination of Platelet Survival" @default.
- W2944995250 doi "https://doi.org/10.1055/s-0039-1680627" @default.
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