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- W2945011574 abstract "Polycomb group (PcG) and Trithorax group (TrxG) proteins orchestrate development of a multicellular organism by faithfully maintaining cell fate decisions made early in embryogenesis. An important chromatin mark connected to PcG/TrxG regulation is bivalent domains, the simultaneous presence of H3K27me3 and H3K4me3 on a given locus, originally identified in mammalian embryonic stem cells but considered to be absent in invertebrates. Here, we provide evidence for the existence of bivalency in fly embryos. Using a recently described PcG reporter fly line, we observed a strong reporter inducibility in the embryo and its sharp decrease in larval and adult stages. Analysis of the chromatin landscape of the reporter revealed a strong signal for the repressive PcG mark, H3K27me3, in all three developmental stages and, surprisingly, a strong signal for a transcriptionally activating H3K4me3 mark in the embryo. Using re-chromatin immunoprecipitation experiments, bivalent domains were also uncovered at endogenous PcG targets like the Hox genes." @default.
- W2945011574 created "2019-05-29" @default.
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- W2945011574 date "2019-05-25" @default.
- W2945011574 modified "2023-10-14" @default.
- W2945011574 title "Bivalency in <i>Drosophila</i> embryos is associated with strong inducibility of Polycomb target genes" @default.
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- W2945011574 doi "https://doi.org/10.1080/19336934.2019.1619438" @default.
- W2945011574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6988889" @default.
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