FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945012235> ?p ?o ?g. }

• W2945012235 endingPage "117149" @default.
• W2945012235 startingPage "117149" @default.
• W2945012235 abstract "Bisphenol A (BPA) as a chemical raw material, is widely used in the manufacturing process of daily necessities. It was reported that BPA could induce oxidative stress, and catalase (CAT) can protect the body from oxidative stress. In this paper, the effect of BPA on CAT was carried out in vitro and in vivo. Firstly, we studied the effects of BPA on oxidative stress, cell viability and CAT activity in human hepatocytes, and the results of vitro experiments show that the survival rate of hepatocytes significant decreased along with the increase of BPA concentration. And when the BPA concentration was 100 μM, the hepatocyte survival decreased by 13.2%, ROS levels in the cells increased by 85%. However, the activity of intracellular CAT increased with the increasing concentration of BPA in 24 h. The results of vivo experiments showed that the activity of CAT in the high-dose group decreased by 29.1% compared with the control group. The long-term effects of BPA on rats reduced the CAT activity in liver, which reduced the resistance to oxidative stress. Meanwhile, the interaction mechanism between BPA and CAT at the molecule level was performed via multiple spectra methods and molecular docking, and the results illustrated that the structural change of CAT is mainly due to the strong combination of BPA with the residues of Trp185. In addition, the interaction mechanism between BPA and CAT were hydrophobic and electrostatic effect. This study provided experimental evidence for better understanding the toxicity of BPA." @default.
• W2945012235 created "2019-05-29" @default.
• W2945012235 creator A5005639848 @default.
• W2945012235 creator A5023578647 @default.
• W2945012235 creator A5031427950 @default.
• W2945012235 creator A5037557702 @default.
• W2945012235 creator A5042188539 @default.
• W2945012235 creator A5043361334 @default.
• W2945012235 creator A5060302685 @default.
• W2945012235 creator A5087571156 @default.
• W2945012235 creator A5088281543 @default.
• W2945012235 date "2019-10-01" @default.
• W2945012235 modified "2023-10-14" @default.
• W2945012235 title "Investigation of the effect for bisphenol A on oxidative stress in human hepatocytes and its interaction with catalase" @default.
• W2945012235 cites W1589556458 @default.
• W2945012235 cites W1596809281 @default.
• W2945012235 cites W1815105172 @default.
• W2945012235 cites W1963654740 @default.
• W2945012235 cites W1970358298 @default.
• W2945012235 cites W1977848104 @default.
• W2945012235 cites W1989046847 @default.
• W2945012235 cites W1991036264 @default.
• W2945012235 cites W2044598637 @default.
• W2945012235 cites W2059544089 @default.
• W2945012235 cites W2067819185 @default.
• W2945012235 cites W2075078593 @default.
• W2945012235 cites W2075705506 @default.
• W2945012235 cites W2081029871 @default.
• W2945012235 cites W2081519024 @default.
• W2945012235 cites W2141230550 @default.
• W2945012235 cites W2152586799 @default.
• W2945012235 cites W2168148786 @default.
• W2945012235 cites W2560783852 @default.
• W2945012235 cites W2768533111 @default.
• W2945012235 cites W2776837346 @default.
• W2945012235 cites W2792750869 @default.
• W2945012235 cites W2883206924 @default.
• W2945012235 cites W74915716 @default.
• W2945012235 doi "https://doi.org/10.1016/j.saa.2019.117149" @default.
• W2945012235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31153119" @default.
• W2945012235 hasPublicationYear "2019" @default.
• W2945012235 type Work @default.
• W2945012235 sameAs 2945012235 @default.
• W2945012235 citedByCount "24" @default.
• W2945012235 countsByYear W29450122352019 @default.
• W2945012235 countsByYear W29450122352020 @default.
• W2945012235 countsByYear W29450122352021 @default.
• W2945012235 countsByYear W29450122352022 @default.
• W2945012235 countsByYear W29450122352023 @default.
• W2945012235 crossrefType "journal-article" @default.
• W2945012235 hasAuthorship W2945012235A5005639848 @default.
• W2945012235 hasAuthorship W2945012235A5023578647 @default.
• W2945012235 hasAuthorship W2945012235A5031427950 @default.
• W2945012235 hasAuthorship W2945012235A5037557702 @default.
• W2945012235 hasAuthorship W2945012235A5042188539 @default.
• W2945012235 hasAuthorship W2945012235A5043361334 @default.
• W2945012235 hasAuthorship W2945012235A5060302685 @default.
• W2945012235 hasAuthorship W2945012235A5087571156 @default.
• W2945012235 hasAuthorship W2945012235A5088281543 @default.
• W2945012235 hasConcept C12554922 @default.
• W2945012235 hasConcept C150903083 @default.
• W2945012235 hasConcept C166595027 @default.
• W2945012235 hasConcept C178790620 @default.
• W2945012235 hasConcept C185592680 @default.
• W2945012235 hasConcept C202751555 @default.
• W2945012235 hasConcept C207001950 @default.
• W2945012235 hasConcept C2776151105 @default.
• W2945012235 hasConcept C2776200302 @default.
• W2945012235 hasConcept C2778979269 @default.
• W2945012235 hasConcept C2779684741 @default.
• W2945012235 hasConcept C29730261 @default.
• W2945012235 hasConcept C55493867 @default.
• W2945012235 hasConcept C57600042 @default.
• W2945012235 hasConcept C79879829 @default.
• W2945012235 hasConcept C86803240 @default.
• W2945012235 hasConcept C98274493 @default.
• W2945012235 hasConceptScore W2945012235C12554922 @default.
• W2945012235 hasConceptScore W2945012235C150903083 @default.
• W2945012235 hasConceptScore W2945012235C166595027 @default.
• W2945012235 hasConceptScore W2945012235C178790620 @default.
• W2945012235 hasConceptScore W2945012235C185592680 @default.
• W2945012235 hasConceptScore W2945012235C202751555 @default.
• W2945012235 hasConceptScore W2945012235C207001950 @default.
• W2945012235 hasConceptScore W2945012235C2776151105 @default.
• W2945012235 hasConceptScore W2945012235C2776200302 @default.
• W2945012235 hasConceptScore W2945012235C2778979269 @default.
• W2945012235 hasConceptScore W2945012235C2779684741 @default.
• W2945012235 hasConceptScore W2945012235C29730261 @default.
• W2945012235 hasConceptScore W2945012235C55493867 @default.
• W2945012235 hasConceptScore W2945012235C57600042 @default.
• W2945012235 hasConceptScore W2945012235C79879829 @default.
• W2945012235 hasConceptScore W2945012235C86803240 @default.
• W2945012235 hasConceptScore W2945012235C98274493 @default.
• W2945012235 hasFunder F4320321001 @default.
• W2945012235 hasFunder F4320326687 @default.
• W2945012235 hasLocation W29450122351 @default.
• W2945012235 hasLocation W29450122352 @default.
• W2945012235 hasOpenAccess W2945012235 @default.

• next