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- W2945013480 abstract "Abstract Background Tumor cells can shed from the tumor, enter the circulation and travel to distant organs, where they can seed metastases. These cells are called circulating tumor cells (CTCs). The ability of CTCs to populate distant tissues and organs has led us to believe they are the primary cause of cancer metastasis. The biological properties and interaction of CTCs with other cell types during intravasation, circulation in the bloodstream, extravasation and colonization are multifaceted and include changes of CTC phenotypes that are regulated by many signaling molecules, including cytokines and chemokines. Considering a sample is readily accessible by a simple blood draw, monitoring CTC levels in the blood has exceptional implications in oncology field. A method called the liquid biopsy allows the extraction of not only CTC, but also CTC products, such as cell free DNA (cfDNA), cell free RNA (cfRNA), microRNA (miRNA) and exosomes. Conclusions The clinical utility of CTCs and their products is increasing with advances in liquid biopsy technology. Clinical applications of liquid biopsy to detect CTCs and their products are numerous and could be used for screening of the presence of the cancer in the general population, as well as for prognostic and predictive biomarkers in cancer patients. With the development of better CTC isolation technologies and clinical testing in large prospective trials, increasing clinical utility of CTCs can be expected. The understanding of their biology and interactions with other cell types, particularly with those of the immune system and the rise of immunotherapy also hold great promise for novel therapeutic possibilities." @default.
- W2945013480 created "2019-05-29" @default.
- W2945013480 creator A5006391058 @default.
- W2945013480 creator A5011945886 @default.
- W2945013480 creator A5040222086 @default.
- W2945013480 creator A5061936570 @default.
- W2945013480 creator A5070257255 @default.
- W2945013480 date "2019-05-08" @default.
- W2945013480 modified "2023-10-02" @default.
- W2945013480 title "The biology and clinical potential of circulating tumor cells" @default.
- W2945013480 cites W1522943140 @default.
- W2945013480 cites W1524250143 @default.
- W2945013480 cites W1553190740 @default.
- W2945013480 cites W1581655059 @default.
- W2945013480 cites W1601681275 @default.
- W2945013480 cites W1607276234 @default.
- W2945013480 cites W1689351220 @default.
- W2945013480 cites W1792291729 @default.
- W2945013480 cites W1844925317 @default.
- W2945013480 cites W1847261877 @default.
- W2945013480 cites W1900545099 @default.
- W2945013480 cites W1939817548 @default.
- W2945013480 cites W1952921626 @default.
- W2945013480 cites W1956237592 @default.
- W2945013480 cites W1959742401 @default.
- W2945013480 cites W1968820371 @default.
- W2945013480 cites W1971589201 @default.
- W2945013480 cites W1974950800 @default.
- W2945013480 cites W1976099137 @default.
- W2945013480 cites W1981521674 @default.
- W2945013480 cites W1985502949 @default.
- W2945013480 cites W1985614501 @default.
- W2945013480 cites W1985662208 @default.
- W2945013480 cites W1986471913 @default.
- W2945013480 cites W1990120645 @default.
- W2945013480 cites W1993913242 @default.
- W2945013480 cites W1994395871 @default.
- W2945013480 cites W1995747176 @default.
- W2945013480 cites W1996145004 @default.
- W2945013480 cites W1999087873 @default.
- W2945013480 cites W2002157461 @default.
- W2945013480 cites W2004228980 @default.
- W2945013480 cites W2012987872 @default.
- W2945013480 cites W2014260136 @default.
- W2945013480 cites W2015751557 @default.
- W2945013480 cites W2016360721 @default.
- W2945013480 cites W2016741520 @default.
- W2945013480 cites W2017336455 @default.
- W2945013480 cites W2018038784 @default.
- W2945013480 cites W2018579586 @default.
- W2945013480 cites W2021205350 @default.
- W2945013480 cites W2022616393 @default.
- W2945013480 cites W2024783386 @default.
- W2945013480 cites W2026759417 @default.
- W2945013480 cites W2028672331 @default.
- W2945013480 cites W2029864630 @default.
- W2945013480 cites W2032192339 @default.
- W2945013480 cites W2032651612 @default.
- W2945013480 cites W2033601733 @default.
- W2945013480 cites W2034030378 @default.
- W2945013480 cites W2034255256 @default.
- W2945013480 cites W2035677696 @default.
- W2945013480 cites W2038151856 @default.
- W2945013480 cites W2040191699 @default.
- W2945013480 cites W2043166238 @default.
- W2945013480 cites W2053380667 @default.
- W2945013480 cites W2059216224 @default.
- W2945013480 cites W2067829376 @default.
- W2945013480 cites W2068503417 @default.
- W2945013480 cites W2071886141 @default.
- W2945013480 cites W2078904004 @default.
- W2945013480 cites W2079032404 @default.
- W2945013480 cites W2080244053 @default.
- W2945013480 cites W2082818778 @default.
- W2945013480 cites W2082833890 @default.
- W2945013480 cites W2084659308 @default.
- W2945013480 cites W2085322507 @default.
- W2945013480 cites W2085524876 @default.
- W2945013480 cites W2086402866 @default.
- W2945013480 cites W2087208912 @default.
- W2945013480 cites W2088107574 @default.
- W2945013480 cites W2090360086 @default.
- W2945013480 cites W2096636873 @default.
- W2945013480 cites W2097849024 @default.
- W2945013480 cites W2097862336 @default.
- W2945013480 cites W2098152005 @default.
- W2945013480 cites W2099367648 @default.
- W2945013480 cites W2099638559 @default.
- W2945013480 cites W2100115202 @default.
- W2945013480 cites W2100568503 @default.
- W2945013480 cites W2101004633 @default.
- W2945013480 cites W2102198783 @default.
- W2945013480 cites W2102864709 @default.
- W2945013480 cites W2103793201 @default.
- W2945013480 cites W2106181914 @default.
- W2945013480 cites W2106572080 @default.
- W2945013480 cites W2108816382 @default.
- W2945013480 cites W2109561657 @default.