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- W2945013547 abstract "Abstract The first example of an octadentate gadolinium unit based on DO3A (hydration number q =1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity ( r 1 ) from 4.0 m m −1 s −1 in unbound form to 34.3 m m −1 s −1 (at 10 MHz, 37 °C) and 22±2 m m −1 s −1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The one‐pot synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units for biocompatibility (PEG and thioglucose units) and targeting (folic acid) leads to little detrimental effect on the high relaxivity observed for these non‐toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies." @default.
- W2945013547 created "2019-05-29" @default.
- W2945013547 creator A5001056234 @default.
- W2945013547 creator A5007170523 @default.
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- W2945013547 creator A5067212029 @default.
- W2945013547 creator A5086866155 @default.
- W2945013547 creator A5091773566 @default.
- W2945013547 date "2019-07-17" @default.
- W2945013547 modified "2023-10-15" @default.
- W2945013547 title "Polyfunctionalised Nanoparticles Bearing Robust Gadolinium Surface Units for High Relaxivity Performance in MRI" @default.
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